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SH003 activates autophagic cell death by activating ATF4 and inhibiting G9a under hypoxia in gastric cancer cells

In gastric cancer (GC), hypoxia is one of the greatest obstacles to cancer therapy. In this present study, we report that SH003, an herbal formulation, induces ER stress via PERK-ATF4-CHOP signaling in GC. SH003-mediated ER stress inhibits G9a, a histone methyltransferase, by reducing STAT3 phosphor...

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Detalles Bibliográficos
Autores principales:	Kim, Tae Woo, Cheon, Chunhoo, Ko, Seong-Gyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468158/ https://www.ncbi.nlm.nih.gov/pubmed/32879309 http://dx.doi.org/10.1038/s41419-020-02924-w

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