FGF/FGFR signaling in health and disease

Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of...

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Autores principales: Xie, Yangli, Su, Nan, Yang, Jing, Tan, Qiaoyan, Huang, Shuo, Jin, Min, Ni, Zhenhong, Zhang, Bin, Zhang, Dali, Luo, Fengtao, Chen, Hangang, Sun, Xianding, Feng, Jian Q., Qi, Huabing, Chen, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468161/
https://www.ncbi.nlm.nih.gov/pubmed/32879300
http://dx.doi.org/10.1038/s41392-020-00222-7
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author Xie, Yangli
Su, Nan
Yang, Jing
Tan, Qiaoyan
Huang, Shuo
Jin, Min
Ni, Zhenhong
Zhang, Bin
Zhang, Dali
Luo, Fengtao
Chen, Hangang
Sun, Xianding
Feng, Jian Q.
Qi, Huabing
Chen, Lin
author_facet Xie, Yangli
Su, Nan
Yang, Jing
Tan, Qiaoyan
Huang, Shuo
Jin, Min
Ni, Zhenhong
Zhang, Bin
Zhang, Dali
Luo, Fengtao
Chen, Hangang
Sun, Xianding
Feng, Jian Q.
Qi, Huabing
Chen, Lin
author_sort Xie, Yangli
collection PubMed
description Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.
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spelling pubmed-74681612020-09-16 FGF/FGFR signaling in health and disease Xie, Yangli Su, Nan Yang, Jing Tan, Qiaoyan Huang, Shuo Jin, Min Ni, Zhenhong Zhang, Bin Zhang, Dali Luo, Fengtao Chen, Hangang Sun, Xianding Feng, Jian Q. Qi, Huabing Chen, Lin Signal Transduct Target Ther Review Article Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems. Nature Publishing Group UK 2020-09-02 /pmc/articles/PMC7468161/ /pubmed/32879300 http://dx.doi.org/10.1038/s41392-020-00222-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Xie, Yangli
Su, Nan
Yang, Jing
Tan, Qiaoyan
Huang, Shuo
Jin, Min
Ni, Zhenhong
Zhang, Bin
Zhang, Dali
Luo, Fengtao
Chen, Hangang
Sun, Xianding
Feng, Jian Q.
Qi, Huabing
Chen, Lin
FGF/FGFR signaling in health and disease
title FGF/FGFR signaling in health and disease
title_full FGF/FGFR signaling in health and disease
title_fullStr FGF/FGFR signaling in health and disease
title_full_unstemmed FGF/FGFR signaling in health and disease
title_short FGF/FGFR signaling in health and disease
title_sort fgf/fgfr signaling in health and disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468161/
https://www.ncbi.nlm.nih.gov/pubmed/32879300
http://dx.doi.org/10.1038/s41392-020-00222-7
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