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Adoptive immunotherapy for gastric cancer using zoledronate-activated killer cells: A prospective observational study

For several years, adoptive immunotherapy (AIT) has been performed using autologous zoledronate-activated killer (ZAK) cells to develop a novel modality for cancer treatment. In the current study, data from 50 patients with incurable gastric cancer were analyzed. Patients were treated with AIT using...

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Autores principales: Yamaguchi, Yoshiyuki, Katata, Yousuke, Sano, Fuminori, Tanioka, Hiroaki, Okawaki, Makoto, Yamamura, Masahiro, Nagasaka, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468212/
https://www.ncbi.nlm.nih.gov/pubmed/32905239
http://dx.doi.org/10.3892/mco.2020.2125
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author Yamaguchi, Yoshiyuki
Katata, Yousuke
Sano, Fuminori
Tanioka, Hiroaki
Okawaki, Makoto
Yamamura, Masahiro
Nagasaka, Takeshi
author_facet Yamaguchi, Yoshiyuki
Katata, Yousuke
Sano, Fuminori
Tanioka, Hiroaki
Okawaki, Makoto
Yamamura, Masahiro
Nagasaka, Takeshi
author_sort Yamaguchi, Yoshiyuki
collection PubMed
description For several years, adoptive immunotherapy (AIT) has been performed using autologous zoledronate-activated killer (ZAK) cells to develop a novel modality for cancer treatment. In the current study, data from 50 patients with incurable gastric cancer were analyzed. Patients were treated with AIT using intravenous ZAK cells every 3-4 weeks in combination with chemotherapy of the physician’s choice. The possible clinical benefits were subsequently examined. The median overall survival (OS) time of all patients was 7.5 months. In patients that received 5 or more rounds of treatment, the OS was 13.5 months. Additionally, the OS times of 1st, 2nd or later line chemotherapy with ZAK cell AIT were 27.3 months and 13.3 months, respectively. No objective response was observed and the disease control rate was 67.9%. No severe adverse event was recorded. Functional Assessment of Cancer Therapy-Biologic Response Modifier analysis revealed possible improvement of quality of life after ZAK cell AIT. Univariate analysis revealed a significant positive association between longer survival times and baseline lymphocyte percentages in white blood cell counts (P<0.001), serum albumin (P=0.001), C-reactive protein (P=0.006), carbohydrate antigen (CA)19-9 (P=0.010), neutrophil-lymphocyte ratio (P<0.001) and Glasgow prognostic score (GPS). Only the GPS value (P=0.024) was a significant survival marker when analyzed using the multivariate Cox proportional hazards model. Although the results cannot provide a definitive conclusion, the current suggested that ZAK cell AIT in combination with chemotherapy is safe, feasible and may be a promising treatment option for patients with incurable gastric cancer. The GPS value at baseline may be a potential biomarker for chemo-immunotherapy.
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spelling pubmed-74682122020-09-03 Adoptive immunotherapy for gastric cancer using zoledronate-activated killer cells: A prospective observational study Yamaguchi, Yoshiyuki Katata, Yousuke Sano, Fuminori Tanioka, Hiroaki Okawaki, Makoto Yamamura, Masahiro Nagasaka, Takeshi Mol Clin Oncol Articles For several years, adoptive immunotherapy (AIT) has been performed using autologous zoledronate-activated killer (ZAK) cells to develop a novel modality for cancer treatment. In the current study, data from 50 patients with incurable gastric cancer were analyzed. Patients were treated with AIT using intravenous ZAK cells every 3-4 weeks in combination with chemotherapy of the physician’s choice. The possible clinical benefits were subsequently examined. The median overall survival (OS) time of all patients was 7.5 months. In patients that received 5 or more rounds of treatment, the OS was 13.5 months. Additionally, the OS times of 1st, 2nd or later line chemotherapy with ZAK cell AIT were 27.3 months and 13.3 months, respectively. No objective response was observed and the disease control rate was 67.9%. No severe adverse event was recorded. Functional Assessment of Cancer Therapy-Biologic Response Modifier analysis revealed possible improvement of quality of life after ZAK cell AIT. Univariate analysis revealed a significant positive association between longer survival times and baseline lymphocyte percentages in white blood cell counts (P<0.001), serum albumin (P=0.001), C-reactive protein (P=0.006), carbohydrate antigen (CA)19-9 (P=0.010), neutrophil-lymphocyte ratio (P<0.001) and Glasgow prognostic score (GPS). Only the GPS value (P=0.024) was a significant survival marker when analyzed using the multivariate Cox proportional hazards model. Although the results cannot provide a definitive conclusion, the current suggested that ZAK cell AIT in combination with chemotherapy is safe, feasible and may be a promising treatment option for patients with incurable gastric cancer. The GPS value at baseline may be a potential biomarker for chemo-immunotherapy. D.A. Spandidos 2020-11 2020-08-24 /pmc/articles/PMC7468212/ /pubmed/32905239 http://dx.doi.org/10.3892/mco.2020.2125 Text en Copyright: © Yamaguchi et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Yamaguchi, Yoshiyuki
Katata, Yousuke
Sano, Fuminori
Tanioka, Hiroaki
Okawaki, Makoto
Yamamura, Masahiro
Nagasaka, Takeshi
Adoptive immunotherapy for gastric cancer using zoledronate-activated killer cells: A prospective observational study
title Adoptive immunotherapy for gastric cancer using zoledronate-activated killer cells: A prospective observational study
title_full Adoptive immunotherapy for gastric cancer using zoledronate-activated killer cells: A prospective observational study
title_fullStr Adoptive immunotherapy for gastric cancer using zoledronate-activated killer cells: A prospective observational study
title_full_unstemmed Adoptive immunotherapy for gastric cancer using zoledronate-activated killer cells: A prospective observational study
title_short Adoptive immunotherapy for gastric cancer using zoledronate-activated killer cells: A prospective observational study
title_sort adoptive immunotherapy for gastric cancer using zoledronate-activated killer cells: a prospective observational study
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468212/
https://www.ncbi.nlm.nih.gov/pubmed/32905239
http://dx.doi.org/10.3892/mco.2020.2125
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