MDA5 cleavage by the Leader protease of foot-and-mouth disease virus reveals its pleiotropic effect against the host antiviral response

The RIG-I-like receptor (RLR) melanoma differentiation-associated gene 5 (MDA5) plays a key role in triggering innate antiviral response during infection by RNA viruses. MDA5 activation leads to transcription induction of type-I interferon (IFN) and proinflammatory cytokines. MDA5 has also been asso...

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Detalles Bibliográficos
Autores principales: Pulido, Miguel Rodríguez, Martínez-Salas, Encarnación, Sobrino, Francisco, Sáiz, Margarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468288/
https://www.ncbi.nlm.nih.gov/pubmed/32879301
http://dx.doi.org/10.1038/s41419-020-02931-x

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