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Ouabain impairs cancer metabolism and activates AMPK-Src signaling pathway in human cancer cell lines
In addition to the well-known cardiotonic effects, cardiac glycosides (CGs) produce potent anticancer effects with various molecular mechanisms. We previously show that ouabain induces autophagic cell death in human lung cancer cells by regulating AMPK-mediated mTOR and Src-mediated ERK1/2 signaling...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Singapore
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468359/ https://www.ncbi.nlm.nih.gov/pubmed/31515527 http://dx.doi.org/10.1038/s41401-019-0290-0 |