Physiologically based pharmacokinetic–pharmacodynamic modeling for prediction of vonoprazan pharmacokinetics and its inhibition on gastric acid secretion following intravenous/oral administration to rats, dogs and humans

Vonoprazan is characterized as having a long-lasting antisecretory effect on gastric acid. In this study we developed a physiologically based pharmacokinetic (PBPK)-pharmacodynamic (PD) model linking to stomach to simultaneously predict vonoprazan pharmacokinetics and its antisecretory effects follo...

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Detalles Bibliográficos
Autores principales: Kong, Wei-min, Sun, Bin-bin, Wang, Zhong-jian, Zheng, Xiao-ke, Zhao, Kai-jing, Chen, Yang, Zhang, Jia-xin, Liu, Pei-hua, Zhu, Liang, Xu, Ru-jun, Li, Ping, Liu, Li, Liu, Xiao-dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468366/
https://www.ncbi.nlm.nih.gov/pubmed/31969689
http://dx.doi.org/10.1038/s41401-019-0353-2

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