Evidence for Disruption of Mg(2+) Pair as a Resistance Mechanism Against HIV-1 Integrase Strand Transfer Inhibitors

HIV-1 integrase is the enzyme responsible for integrating the viral DNA into the host genome and is one of the main targets for antiretroviral therapy; however, there are documented cases of resistance against all the currently used integrase strand transfer inhibitors (INSTIs). While some resistanc...

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Detalles Bibliográficos
Autores principales: Machado, Lucas de Almeida, Guimarães, Ana Carolina Ramos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468422/
https://www.ncbi.nlm.nih.gov/pubmed/32974383
http://dx.doi.org/10.3389/fmolb.2020.00170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468422/
https://www.ncbi.nlm.nih.gov/pubmed/32974383
http://dx.doi.org/10.3389/fmolb.2020.00170

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