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Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke

Cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 are two crucial mediators contributing to blood-brain barrier (BBB) damage during cerebral ischemia. However, it is not known whether MMP-9 activation is involved in COX-2-mediated BBB disruption in ischemic stroke. In this study, we hypoth...

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Detalles Bibliográficos
Autores principales:	Yang, Changjun, Yang, Yi, DeMars, Kelly M., Rosenberg, Gary A., Candelario-Jalil, Eduardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neurology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468510/ https://www.ncbi.nlm.nih.gov/pubmed/32973660 http://dx.doi.org/10.3389/fneur.2020.00887

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