Development and characterization of an inducible Dicer conditional knockout mouse model of Parkinson’s disease: validation of the antiparkinsonian effects of a sigma-1 receptor agonist and dihydromyricetin

Parkinson’s disease (PD) is a common neurodegenerative disease characterized by motor impairment and progressive loss of dopamine (DA) neurons. At present, the acute application of neurotoxic drugs such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are commonl...

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Detalles Bibliográficos
Autores principales: Guo, Chen-hong, Cao, Ting, Zheng, Long-tai, Waddington, John L, Zhen, Xue-chu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468551/
https://www.ncbi.nlm.nih.gov/pubmed/32112040
http://dx.doi.org/10.1038/s41401-020-0379-5

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