Mebendazole elicits potent antimyeloma activity by inhibiting the USP5/c-Maf axis

c-Maf is a critical oncogenic transcription factor that contributes to myelomagenesis. Our previous studies demonstrated that the deubiquitinase USP5 stabilizes c-Maf and promotes myeloma cell proliferation and survival; therefore, the USP5/c-Maf axis could be a potential target for myeloma therapy....

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Xue-han, Xu, Yu-jia, Wang, Xiao-ge, Lin, Peng, Cao, Bi-yin, Zeng, Yuan-ying, Wang, Qi, Zhang, Zu-bin, Mao, Xin-liang, Zhang, Tie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468578/
https://www.ncbi.nlm.nih.gov/pubmed/31197245
http://dx.doi.org/10.1038/s41401-019-0249-1

Ejemplares similares

Ejemplares similares