Mislocalization of TORC1 to Lysosomes Caused by KIF11 Inhibition Leads to Aberrant TORC1 Activity

While the growth factors like insulin initiate a signaling cascade to induce conformational changes in the mechanistic target of rapamycin complex 1 (mTORC1), amino acids cause the complex to localize to the site of activation, the lysosome. The precise mechanism of how mTORC1 moves in and out of th...

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Detalles Bibliográficos
Autores principales: Jang, Yoon-Gu, Choi, Yujin, Jun, Kyoungho, Chung, Jongkyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468583/
https://www.ncbi.nlm.nih.gov/pubmed/32759469
http://dx.doi.org/10.14348/molcells.2020.0089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468583/
https://www.ncbi.nlm.nih.gov/pubmed/32759469
http://dx.doi.org/10.14348/molcells.2020.0089

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