Cargando…
The Anterior Chamber Injection of Moxifloxacin Injection to Prevent Endophthalmitis after Cataract Surgery: A Meta-analysis
PURPOSE: A meta-analysis was performed to compare the efficacy of an anterior chamber injection of moxifloxacin in the prevention of endophthalmitis after cataract surgery. METHODS: A computer-based search of PubMed, Embase, the Cochrane Library, and the Clinical Trial database for articles related...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468651/ https://www.ncbi.nlm.nih.gov/pubmed/32908685 http://dx.doi.org/10.1155/2020/7242969 |
_version_ | 1783578264694947840 |
---|---|
author | Wang, Xiao-lei Huang, Xiao-yong Wang, Zhen Sun, Wei |
author_facet | Wang, Xiao-lei Huang, Xiao-yong Wang, Zhen Sun, Wei |
author_sort | Wang, Xiao-lei |
collection | PubMed |
description | PURPOSE: A meta-analysis was performed to compare the efficacy of an anterior chamber injection of moxifloxacin in the prevention of endophthalmitis after cataract surgery. METHODS: A computer-based search of PubMed, Embase, the Cochrane Library, and the Clinical Trial database for articles related to anterior intraventricular injection of moxifloxacin for the prevention of endophthalmitis after cataract surgery was performed through April 2019. Study selection, data exclusion, and quality assessment were performed by two independent observers. Statistical analysis for the meta-analysis was performed by RevMan5.3 software. RESULTS: Eight studies were included, with a total of 123,819 eyes. The meta-analysis showed that an anterior chamber injection of moxifloxacin can prevent the incidence of endophthalmitis after cataract surgery (OR = 0.29, 95% CI (0.15, 0.56), P=0.0002), and the difference was statistically significant. There were no significant differences between the moxifloxacin injection and nonmoxifloxacin injection groups in regard to UCVA (log MAR) (SMD = −0.13, 95% CI (−0.62, 0.35), P=0.60), BCVA (log MAR) (SMD = −0.27, 95% CI (−1.28, 0.74), P=0.60), IOP (SMD = −0.04, 95% CI (−0.02, 0.01), P=0.22), corneal edema (OR = 1.03, 95% CI (0.23, 4.69), P=0.97), CCT (SMD = −0.01, 95% CI (−0.07, 0.05), P=0.77), or ECD (SMD = 0.00, 95% CI (−0.06, 0.07), P=0.94). CONCLUSION: An anterior chamber injection of moxifloxacin can effectively prevent the incidence of endophthalmitis after cataract surgery, while the moxifloxacin injection and nonmoxifloxacin injection groups had similar results in regard to UCVA (log MAR), BCVA (log MAR), IOP, corneal edema, CCT, and ECD. |
format | Online Article Text |
id | pubmed-7468651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-74686512020-09-08 The Anterior Chamber Injection of Moxifloxacin Injection to Prevent Endophthalmitis after Cataract Surgery: A Meta-analysis Wang, Xiao-lei Huang, Xiao-yong Wang, Zhen Sun, Wei J Ophthalmol Research Article PURPOSE: A meta-analysis was performed to compare the efficacy of an anterior chamber injection of moxifloxacin in the prevention of endophthalmitis after cataract surgery. METHODS: A computer-based search of PubMed, Embase, the Cochrane Library, and the Clinical Trial database for articles related to anterior intraventricular injection of moxifloxacin for the prevention of endophthalmitis after cataract surgery was performed through April 2019. Study selection, data exclusion, and quality assessment were performed by two independent observers. Statistical analysis for the meta-analysis was performed by RevMan5.3 software. RESULTS: Eight studies were included, with a total of 123,819 eyes. The meta-analysis showed that an anterior chamber injection of moxifloxacin can prevent the incidence of endophthalmitis after cataract surgery (OR = 0.29, 95% CI (0.15, 0.56), P=0.0002), and the difference was statistically significant. There were no significant differences between the moxifloxacin injection and nonmoxifloxacin injection groups in regard to UCVA (log MAR) (SMD = −0.13, 95% CI (−0.62, 0.35), P=0.60), BCVA (log MAR) (SMD = −0.27, 95% CI (−1.28, 0.74), P=0.60), IOP (SMD = −0.04, 95% CI (−0.02, 0.01), P=0.22), corneal edema (OR = 1.03, 95% CI (0.23, 4.69), P=0.97), CCT (SMD = −0.01, 95% CI (−0.07, 0.05), P=0.77), or ECD (SMD = 0.00, 95% CI (−0.06, 0.07), P=0.94). CONCLUSION: An anterior chamber injection of moxifloxacin can effectively prevent the incidence of endophthalmitis after cataract surgery, while the moxifloxacin injection and nonmoxifloxacin injection groups had similar results in regard to UCVA (log MAR), BCVA (log MAR), IOP, corneal edema, CCT, and ECD. Hindawi 2020-08-25 /pmc/articles/PMC7468651/ /pubmed/32908685 http://dx.doi.org/10.1155/2020/7242969 Text en Copyright © 2020 Xiao-lei Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wang, Xiao-lei Huang, Xiao-yong Wang, Zhen Sun, Wei The Anterior Chamber Injection of Moxifloxacin Injection to Prevent Endophthalmitis after Cataract Surgery: A Meta-analysis |
title | The Anterior Chamber Injection of Moxifloxacin Injection to Prevent Endophthalmitis after Cataract Surgery: A Meta-analysis |
title_full | The Anterior Chamber Injection of Moxifloxacin Injection to Prevent Endophthalmitis after Cataract Surgery: A Meta-analysis |
title_fullStr | The Anterior Chamber Injection of Moxifloxacin Injection to Prevent Endophthalmitis after Cataract Surgery: A Meta-analysis |
title_full_unstemmed | The Anterior Chamber Injection of Moxifloxacin Injection to Prevent Endophthalmitis after Cataract Surgery: A Meta-analysis |
title_short | The Anterior Chamber Injection of Moxifloxacin Injection to Prevent Endophthalmitis after Cataract Surgery: A Meta-analysis |
title_sort | anterior chamber injection of moxifloxacin injection to prevent endophthalmitis after cataract surgery: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468651/ https://www.ncbi.nlm.nih.gov/pubmed/32908685 http://dx.doi.org/10.1155/2020/7242969 |
work_keys_str_mv | AT wangxiaolei theanteriorchamberinjectionofmoxifloxacininjectiontopreventendophthalmitisaftercataractsurgeryametaanalysis AT huangxiaoyong theanteriorchamberinjectionofmoxifloxacininjectiontopreventendophthalmitisaftercataractsurgeryametaanalysis AT wangzhen theanteriorchamberinjectionofmoxifloxacininjectiontopreventendophthalmitisaftercataractsurgeryametaanalysis AT sunwei theanteriorchamberinjectionofmoxifloxacininjectiontopreventendophthalmitisaftercataractsurgeryametaanalysis AT wangxiaolei anteriorchamberinjectionofmoxifloxacininjectiontopreventendophthalmitisaftercataractsurgeryametaanalysis AT huangxiaoyong anteriorchamberinjectionofmoxifloxacininjectiontopreventendophthalmitisaftercataractsurgeryametaanalysis AT wangzhen anteriorchamberinjectionofmoxifloxacininjectiontopreventendophthalmitisaftercataractsurgeryametaanalysis AT sunwei anteriorchamberinjectionofmoxifloxacininjectiontopreventendophthalmitisaftercataractsurgeryametaanalysis |