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Macronutrient Intake from Human Milk, Infant Growth, and Body Composition at Term Equivalent Age: A Longitudinal Study of Hospitalized Very Preterm Infants

The variable macronutrient content of human milk may contribute to growth deficits among preterm infants in the neonatal intensive care unit (NICU). In a longitudinal study of 37 infants < 32 weeks gestation, we aimed to (1) determine the between-infant variation in macronutrient intake from huma...

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Autores principales: Belfort, Mandy, Cherkerzian, Sara, Bell, Katherine, Soldateli, Betina, Cordova Ramos, Erika, Palmer, Caroline, Steele, Tina, Pepin, Hunter, Ellard, Deirdre, Drouin, Kaitlin, Inder, Terrie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468722/
https://www.ncbi.nlm.nih.gov/pubmed/32731348
http://dx.doi.org/10.3390/nu12082249
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author Belfort, Mandy
Cherkerzian, Sara
Bell, Katherine
Soldateli, Betina
Cordova Ramos, Erika
Palmer, Caroline
Steele, Tina
Pepin, Hunter
Ellard, Deirdre
Drouin, Kaitlin
Inder, Terrie
author_facet Belfort, Mandy
Cherkerzian, Sara
Bell, Katherine
Soldateli, Betina
Cordova Ramos, Erika
Palmer, Caroline
Steele, Tina
Pepin, Hunter
Ellard, Deirdre
Drouin, Kaitlin
Inder, Terrie
author_sort Belfort, Mandy
collection PubMed
description The variable macronutrient content of human milk may contribute to growth deficits among preterm infants in the neonatal intensive care unit (NICU). In a longitudinal study of 37 infants < 32 weeks gestation, we aimed to (1) determine the between-infant variation in macronutrient intake from human milk and (2) examine associations of macronutrient intake with growth outcomes. We analyzed 1626 human milk samples (median, 43 samples/infant) with mid infrared spectroscopy. Outcomes at term equivalent age were weight, length, head circumference, fat mass, and fat-free mass. Median (range) intakes from human milk were: protein 1.37 (0.88, 2.43) g/kg/day; fat 4.20 (3.19, 5.82) g/kg/day; carbohydrate 8.94 (7.72, 9.85) g/kg/day; and energy 82.5 (68.7, 99.3) kcal/kg/day. In median regression models adjusted for birth size and gestational age, and other covariates, greater intakes of fat and energy were associated with higher weight (0.61 z-scores per g/kg/day fat, 95% CI 0.21, 1.01; 0.69 z-scores per 10 kcal/kg/day, 95% CI 0.28, 1.10), whereas greater protein intake was associated with greater body length (0.84 z-scores per g/kg/day protein, 95% CI 0.09, 1.58). Higher fat intake was also associated with higher fat mass and fat-free mass. Macronutrient intakes from human milk were highly variable and associated with growth outcomes despite routine fortification.
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spelling pubmed-74687222020-09-04 Macronutrient Intake from Human Milk, Infant Growth, and Body Composition at Term Equivalent Age: A Longitudinal Study of Hospitalized Very Preterm Infants Belfort, Mandy Cherkerzian, Sara Bell, Katherine Soldateli, Betina Cordova Ramos, Erika Palmer, Caroline Steele, Tina Pepin, Hunter Ellard, Deirdre Drouin, Kaitlin Inder, Terrie Nutrients Article The variable macronutrient content of human milk may contribute to growth deficits among preterm infants in the neonatal intensive care unit (NICU). In a longitudinal study of 37 infants < 32 weeks gestation, we aimed to (1) determine the between-infant variation in macronutrient intake from human milk and (2) examine associations of macronutrient intake with growth outcomes. We analyzed 1626 human milk samples (median, 43 samples/infant) with mid infrared spectroscopy. Outcomes at term equivalent age were weight, length, head circumference, fat mass, and fat-free mass. Median (range) intakes from human milk were: protein 1.37 (0.88, 2.43) g/kg/day; fat 4.20 (3.19, 5.82) g/kg/day; carbohydrate 8.94 (7.72, 9.85) g/kg/day; and energy 82.5 (68.7, 99.3) kcal/kg/day. In median regression models adjusted for birth size and gestational age, and other covariates, greater intakes of fat and energy were associated with higher weight (0.61 z-scores per g/kg/day fat, 95% CI 0.21, 1.01; 0.69 z-scores per 10 kcal/kg/day, 95% CI 0.28, 1.10), whereas greater protein intake was associated with greater body length (0.84 z-scores per g/kg/day protein, 95% CI 0.09, 1.58). Higher fat intake was also associated with higher fat mass and fat-free mass. Macronutrient intakes from human milk were highly variable and associated with growth outcomes despite routine fortification. MDPI 2020-07-28 /pmc/articles/PMC7468722/ /pubmed/32731348 http://dx.doi.org/10.3390/nu12082249 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Belfort, Mandy
Cherkerzian, Sara
Bell, Katherine
Soldateli, Betina
Cordova Ramos, Erika
Palmer, Caroline
Steele, Tina
Pepin, Hunter
Ellard, Deirdre
Drouin, Kaitlin
Inder, Terrie
Macronutrient Intake from Human Milk, Infant Growth, and Body Composition at Term Equivalent Age: A Longitudinal Study of Hospitalized Very Preterm Infants
title Macronutrient Intake from Human Milk, Infant Growth, and Body Composition at Term Equivalent Age: A Longitudinal Study of Hospitalized Very Preterm Infants
title_full Macronutrient Intake from Human Milk, Infant Growth, and Body Composition at Term Equivalent Age: A Longitudinal Study of Hospitalized Very Preterm Infants
title_fullStr Macronutrient Intake from Human Milk, Infant Growth, and Body Composition at Term Equivalent Age: A Longitudinal Study of Hospitalized Very Preterm Infants
title_full_unstemmed Macronutrient Intake from Human Milk, Infant Growth, and Body Composition at Term Equivalent Age: A Longitudinal Study of Hospitalized Very Preterm Infants
title_short Macronutrient Intake from Human Milk, Infant Growth, and Body Composition at Term Equivalent Age: A Longitudinal Study of Hospitalized Very Preterm Infants
title_sort macronutrient intake from human milk, infant growth, and body composition at term equivalent age: a longitudinal study of hospitalized very preterm infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468722/
https://www.ncbi.nlm.nih.gov/pubmed/32731348
http://dx.doi.org/10.3390/nu12082249
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