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Dietary Intake of Carotenoid-Rich Vegetables Reduces Visceral Adiposity in Obese Japanese men—A Randomized, Double-Blind Trial

Metabolic syndrome, whose main diagnostic component is obesity, is a risk factor for lifestyle-related diseases, type 2 diabetes, and cardiovascular disease. Diet is known to affect the prevalence of metabolic syndrome. However, the effect of diet on metabolic syndrome in Japanese subjects has not b...

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Autores principales: Takagi, Tomohisa, Hayashi, Ryotaro, Nakai, Yuji, Okada, Shinji, Miyashita, Rumiko, Yamada, Mayumi, Mihara, Yoichi, Mizushima, Katsura, Morita, Mayuko, Uchiyama, Kazuhiko, Naito, Yuji, Itoh, Yoshito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468729/
https://www.ncbi.nlm.nih.gov/pubmed/32764462
http://dx.doi.org/10.3390/nu12082342
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author Takagi, Tomohisa
Hayashi, Ryotaro
Nakai, Yuji
Okada, Shinji
Miyashita, Rumiko
Yamada, Mayumi
Mihara, Yoichi
Mizushima, Katsura
Morita, Mayuko
Uchiyama, Kazuhiko
Naito, Yuji
Itoh, Yoshito
author_facet Takagi, Tomohisa
Hayashi, Ryotaro
Nakai, Yuji
Okada, Shinji
Miyashita, Rumiko
Yamada, Mayumi
Mihara, Yoichi
Mizushima, Katsura
Morita, Mayuko
Uchiyama, Kazuhiko
Naito, Yuji
Itoh, Yoshito
author_sort Takagi, Tomohisa
collection PubMed
description Metabolic syndrome, whose main diagnostic component is obesity, is a risk factor for lifestyle-related diseases, type 2 diabetes, and cardiovascular disease. Diet is known to affect the prevalence of metabolic syndrome. However, the effect of diet on metabolic syndrome in Japanese subjects has not been thoroughly explored. In the present study, we investigated the effect of carotenoid-rich vegetables, particularly lycopene- and lutein-rich vegetables, on the metabolic syndrome in obese Japanese men. We conducted an 8-week long randomized, double-blinded, controlled clinical trial in which, 28 middle-aged (40 ≤ age < 65) Japanese men with high body mass index (BMI ≥ 25) were randomized into four dietary groups: high lycopene + high lutein (HLyHLu), high lycopene + low lutein (HLyLLu), low lycopene + high lutein (LLyHLu), and low lycopene + low lutein (LLyLLu). Our results showed that daily beverage-intake increased the plasma levels of carotenoids without adverse effects, and the visceral fat level was significantly decreased in all the groups. The waist circumference was significantly decreased only in the HLyLLu group, whereas the CoQ10 oxidation rate was decreased in all the groups. The gene expression profiles of whole blood samples before and after ingestion differed only in the LLyLLu group, indicating the effect of carotenoids on gene expression profile. In conclusion, our results suggest that dietary uptake of carotenoid-rich vegetables increases their concentration in blood and reduces the intra-abdominal visceral fat.
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spelling pubmed-74687292020-09-04 Dietary Intake of Carotenoid-Rich Vegetables Reduces Visceral Adiposity in Obese Japanese men—A Randomized, Double-Blind Trial Takagi, Tomohisa Hayashi, Ryotaro Nakai, Yuji Okada, Shinji Miyashita, Rumiko Yamada, Mayumi Mihara, Yoichi Mizushima, Katsura Morita, Mayuko Uchiyama, Kazuhiko Naito, Yuji Itoh, Yoshito Nutrients Article Metabolic syndrome, whose main diagnostic component is obesity, is a risk factor for lifestyle-related diseases, type 2 diabetes, and cardiovascular disease. Diet is known to affect the prevalence of metabolic syndrome. However, the effect of diet on metabolic syndrome in Japanese subjects has not been thoroughly explored. In the present study, we investigated the effect of carotenoid-rich vegetables, particularly lycopene- and lutein-rich vegetables, on the metabolic syndrome in obese Japanese men. We conducted an 8-week long randomized, double-blinded, controlled clinical trial in which, 28 middle-aged (40 ≤ age < 65) Japanese men with high body mass index (BMI ≥ 25) were randomized into four dietary groups: high lycopene + high lutein (HLyHLu), high lycopene + low lutein (HLyLLu), low lycopene + high lutein (LLyHLu), and low lycopene + low lutein (LLyLLu). Our results showed that daily beverage-intake increased the plasma levels of carotenoids without adverse effects, and the visceral fat level was significantly decreased in all the groups. The waist circumference was significantly decreased only in the HLyLLu group, whereas the CoQ10 oxidation rate was decreased in all the groups. The gene expression profiles of whole blood samples before and after ingestion differed only in the LLyLLu group, indicating the effect of carotenoids on gene expression profile. In conclusion, our results suggest that dietary uptake of carotenoid-rich vegetables increases their concentration in blood and reduces the intra-abdominal visceral fat. MDPI 2020-08-05 /pmc/articles/PMC7468729/ /pubmed/32764462 http://dx.doi.org/10.3390/nu12082342 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Takagi, Tomohisa
Hayashi, Ryotaro
Nakai, Yuji
Okada, Shinji
Miyashita, Rumiko
Yamada, Mayumi
Mihara, Yoichi
Mizushima, Katsura
Morita, Mayuko
Uchiyama, Kazuhiko
Naito, Yuji
Itoh, Yoshito
Dietary Intake of Carotenoid-Rich Vegetables Reduces Visceral Adiposity in Obese Japanese men—A Randomized, Double-Blind Trial
title Dietary Intake of Carotenoid-Rich Vegetables Reduces Visceral Adiposity in Obese Japanese men—A Randomized, Double-Blind Trial
title_full Dietary Intake of Carotenoid-Rich Vegetables Reduces Visceral Adiposity in Obese Japanese men—A Randomized, Double-Blind Trial
title_fullStr Dietary Intake of Carotenoid-Rich Vegetables Reduces Visceral Adiposity in Obese Japanese men—A Randomized, Double-Blind Trial
title_full_unstemmed Dietary Intake of Carotenoid-Rich Vegetables Reduces Visceral Adiposity in Obese Japanese men—A Randomized, Double-Blind Trial
title_short Dietary Intake of Carotenoid-Rich Vegetables Reduces Visceral Adiposity in Obese Japanese men—A Randomized, Double-Blind Trial
title_sort dietary intake of carotenoid-rich vegetables reduces visceral adiposity in obese japanese men—a randomized, double-blind trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468729/
https://www.ncbi.nlm.nih.gov/pubmed/32764462
http://dx.doi.org/10.3390/nu12082342
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