Cargando…
Design and Validation of a Diet Rich in Slowly Digestible Starch for Type 2 Diabetic Patients for Significant Improvement in Glycemic Profile
This study aimed at designing a—diet high in slowly digestible starch (SDS) by carefully selecting high-SDS starchy products and to validate its implementation, acceptance, and impact on the postprandial glycemic response in patients with type 2 diabetes (T2D). Starchy products were screened and cla...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468810/ https://www.ncbi.nlm.nih.gov/pubmed/32796734 http://dx.doi.org/10.3390/nu12082404 |
_version_ | 1783578295954046976 |
---|---|
author | Goux, Aurélie Breyton, Anne-Esther Meynier, Alexandra Lambert-Porcheron, Stéphanie Sothier, Monique Van Den Berghe, Laurie Brack, Olivier Normand, Sylvie Disse, Emmanuel Laville, Martine Nazare, Julie-Anne Vinoy, Sophie |
author_facet | Goux, Aurélie Breyton, Anne-Esther Meynier, Alexandra Lambert-Porcheron, Stéphanie Sothier, Monique Van Den Berghe, Laurie Brack, Olivier Normand, Sylvie Disse, Emmanuel Laville, Martine Nazare, Julie-Anne Vinoy, Sophie |
author_sort | Goux, Aurélie |
collection | PubMed |
description | This study aimed at designing a—diet high in slowly digestible starch (SDS) by carefully selecting high-SDS starchy products and to validate its implementation, acceptance, and impact on the postprandial glycemic response in patients with type 2 diabetes (T2D). Starchy products were screened and classified as being either high (high-SDS) or low (low-SDS) in SDS (in vitro SDS method). A randomized controlled cross-over pilot study was performed: Eight patients with T2D consumed randomly a high-SDS or a low-SDS diet for one week each, while their glycemic profile was monitored for 6 days. Based on 250 food product SDS analyses and dietary recommendations for patients with T2D, the high-SDS and low-SDS diets were designed. The high-SDS diet significantly increased SDS intake and the SDS/carbohydrates proportion compared to the low-SDS diet (61.6 vs. 11.6 g/day and 30% vs. 6%; p < 0.0001, respectively). Increasing the SDS/carbohydrate proportion to 50% of the meal was significantly correlated with a 12% decrease in tAUC0–120 min and a 14% decrease in the glycemic peak value (p < 0.001 for both). A high-SDS diet can be easily designed by carefully selecting commercial starchy products and providing relevant recommendations for T2D to improve their glycemic profile. |
format | Online Article Text |
id | pubmed-7468810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74688102020-09-04 Design and Validation of a Diet Rich in Slowly Digestible Starch for Type 2 Diabetic Patients for Significant Improvement in Glycemic Profile Goux, Aurélie Breyton, Anne-Esther Meynier, Alexandra Lambert-Porcheron, Stéphanie Sothier, Monique Van Den Berghe, Laurie Brack, Olivier Normand, Sylvie Disse, Emmanuel Laville, Martine Nazare, Julie-Anne Vinoy, Sophie Nutrients Article This study aimed at designing a—diet high in slowly digestible starch (SDS) by carefully selecting high-SDS starchy products and to validate its implementation, acceptance, and impact on the postprandial glycemic response in patients with type 2 diabetes (T2D). Starchy products were screened and classified as being either high (high-SDS) or low (low-SDS) in SDS (in vitro SDS method). A randomized controlled cross-over pilot study was performed: Eight patients with T2D consumed randomly a high-SDS or a low-SDS diet for one week each, while their glycemic profile was monitored for 6 days. Based on 250 food product SDS analyses and dietary recommendations for patients with T2D, the high-SDS and low-SDS diets were designed. The high-SDS diet significantly increased SDS intake and the SDS/carbohydrates proportion compared to the low-SDS diet (61.6 vs. 11.6 g/day and 30% vs. 6%; p < 0.0001, respectively). Increasing the SDS/carbohydrate proportion to 50% of the meal was significantly correlated with a 12% decrease in tAUC0–120 min and a 14% decrease in the glycemic peak value (p < 0.001 for both). A high-SDS diet can be easily designed by carefully selecting commercial starchy products and providing relevant recommendations for T2D to improve their glycemic profile. MDPI 2020-08-11 /pmc/articles/PMC7468810/ /pubmed/32796734 http://dx.doi.org/10.3390/nu12082404 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Goux, Aurélie Breyton, Anne-Esther Meynier, Alexandra Lambert-Porcheron, Stéphanie Sothier, Monique Van Den Berghe, Laurie Brack, Olivier Normand, Sylvie Disse, Emmanuel Laville, Martine Nazare, Julie-Anne Vinoy, Sophie Design and Validation of a Diet Rich in Slowly Digestible Starch for Type 2 Diabetic Patients for Significant Improvement in Glycemic Profile |
title | Design and Validation of a Diet Rich in Slowly Digestible Starch for Type 2 Diabetic Patients for Significant Improvement in Glycemic Profile |
title_full | Design and Validation of a Diet Rich in Slowly Digestible Starch for Type 2 Diabetic Patients for Significant Improvement in Glycemic Profile |
title_fullStr | Design and Validation of a Diet Rich in Slowly Digestible Starch for Type 2 Diabetic Patients for Significant Improvement in Glycemic Profile |
title_full_unstemmed | Design and Validation of a Diet Rich in Slowly Digestible Starch for Type 2 Diabetic Patients for Significant Improvement in Glycemic Profile |
title_short | Design and Validation of a Diet Rich in Slowly Digestible Starch for Type 2 Diabetic Patients for Significant Improvement in Glycemic Profile |
title_sort | design and validation of a diet rich in slowly digestible starch for type 2 diabetic patients for significant improvement in glycemic profile |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468810/ https://www.ncbi.nlm.nih.gov/pubmed/32796734 http://dx.doi.org/10.3390/nu12082404 |
work_keys_str_mv | AT gouxaurelie designandvalidationofadietrichinslowlydigestiblestarchfortype2diabeticpatientsforsignificantimprovementinglycemicprofile AT breytonanneesther designandvalidationofadietrichinslowlydigestiblestarchfortype2diabeticpatientsforsignificantimprovementinglycemicprofile AT meynieralexandra designandvalidationofadietrichinslowlydigestiblestarchfortype2diabeticpatientsforsignificantimprovementinglycemicprofile AT lambertporcheronstephanie designandvalidationofadietrichinslowlydigestiblestarchfortype2diabeticpatientsforsignificantimprovementinglycemicprofile AT sothiermonique designandvalidationofadietrichinslowlydigestiblestarchfortype2diabeticpatientsforsignificantimprovementinglycemicprofile AT vandenberghelaurie designandvalidationofadietrichinslowlydigestiblestarchfortype2diabeticpatientsforsignificantimprovementinglycemicprofile AT brackolivier designandvalidationofadietrichinslowlydigestiblestarchfortype2diabeticpatientsforsignificantimprovementinglycemicprofile AT normandsylvie designandvalidationofadietrichinslowlydigestiblestarchfortype2diabeticpatientsforsignificantimprovementinglycemicprofile AT disseemmanuel designandvalidationofadietrichinslowlydigestiblestarchfortype2diabeticpatientsforsignificantimprovementinglycemicprofile AT lavillemartine designandvalidationofadietrichinslowlydigestiblestarchfortype2diabeticpatientsforsignificantimprovementinglycemicprofile AT nazarejulieanne designandvalidationofadietrichinslowlydigestiblestarchfortype2diabeticpatientsforsignificantimprovementinglycemicprofile AT vinoysophie designandvalidationofadietrichinslowlydigestiblestarchfortype2diabeticpatientsforsignificantimprovementinglycemicprofile |