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Association of Serum Fatty Acids at Admission with the Age of Onset of Acute Ischemic Stroke

Dietary triglycerides influence fatty acid (FA) serum concentrations and weight percentages (wt %), which may be associated with the age of onset of acute ischemic stroke (AIS). We investigated the correlations between serum FA levels and proportions at admission and the age of onset of AIS. We eval...

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Autores principales: Mori, Takahisa, Yoshioka, Kazuhiro, Tanno, Yuhei, Kasakura, Shigen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468942/
https://www.ncbi.nlm.nih.gov/pubmed/32806540
http://dx.doi.org/10.3390/nu12082411
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author Mori, Takahisa
Yoshioka, Kazuhiro
Tanno, Yuhei
Kasakura, Shigen
author_facet Mori, Takahisa
Yoshioka, Kazuhiro
Tanno, Yuhei
Kasakura, Shigen
author_sort Mori, Takahisa
collection PubMed
description Dietary triglycerides influence fatty acid (FA) serum concentrations and weight percentages (wt %), which may be associated with the age of onset of acute ischemic stroke (AIS). We investigated the correlations between serum FA levels and proportions at admission and the age of onset of AIS. We evaluated patients with AIS admitted between 2016 and 2019 within 24 h of AIS onset and calculated the correlation coefficients between their ages, serum FA concentrations, and FA wt % values. Multiple linear regression analysis was performed to identify independent FAs indicating AIS age of onset. Furthermore, we estimated the threshold values of independent FAs for age of onset <60 years using receiver operating characteristic curves by logistic regression. A total of 525 patients (median age: 75 years) met the inclusion criteria. The concentration of dihomo-gamma-linolenic acid (DGLA) and wt % of docosahexaenoic acid (DHA) were significant independent variables for age of onset of AIS, and receiver operating characteristic curves for age of onset <60 years showed thresholds of ≥117.7 µmol/L for DGLA and ≤3.7% for DHA. An increased DGLA concentration and decreased DHA wt % were significantly associated with onset of AIS at a younger age.
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spelling pubmed-74689422020-09-04 Association of Serum Fatty Acids at Admission with the Age of Onset of Acute Ischemic Stroke Mori, Takahisa Yoshioka, Kazuhiro Tanno, Yuhei Kasakura, Shigen Nutrients Article Dietary triglycerides influence fatty acid (FA) serum concentrations and weight percentages (wt %), which may be associated with the age of onset of acute ischemic stroke (AIS). We investigated the correlations between serum FA levels and proportions at admission and the age of onset of AIS. We evaluated patients with AIS admitted between 2016 and 2019 within 24 h of AIS onset and calculated the correlation coefficients between their ages, serum FA concentrations, and FA wt % values. Multiple linear regression analysis was performed to identify independent FAs indicating AIS age of onset. Furthermore, we estimated the threshold values of independent FAs for age of onset <60 years using receiver operating characteristic curves by logistic regression. A total of 525 patients (median age: 75 years) met the inclusion criteria. The concentration of dihomo-gamma-linolenic acid (DGLA) and wt % of docosahexaenoic acid (DHA) were significant independent variables for age of onset of AIS, and receiver operating characteristic curves for age of onset <60 years showed thresholds of ≥117.7 µmol/L for DGLA and ≤3.7% for DHA. An increased DGLA concentration and decreased DHA wt % were significantly associated with onset of AIS at a younger age. MDPI 2020-08-12 /pmc/articles/PMC7468942/ /pubmed/32806540 http://dx.doi.org/10.3390/nu12082411 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mori, Takahisa
Yoshioka, Kazuhiro
Tanno, Yuhei
Kasakura, Shigen
Association of Serum Fatty Acids at Admission with the Age of Onset of Acute Ischemic Stroke
title Association of Serum Fatty Acids at Admission with the Age of Onset of Acute Ischemic Stroke
title_full Association of Serum Fatty Acids at Admission with the Age of Onset of Acute Ischemic Stroke
title_fullStr Association of Serum Fatty Acids at Admission with the Age of Onset of Acute Ischemic Stroke
title_full_unstemmed Association of Serum Fatty Acids at Admission with the Age of Onset of Acute Ischemic Stroke
title_short Association of Serum Fatty Acids at Admission with the Age of Onset of Acute Ischemic Stroke
title_sort association of serum fatty acids at admission with the age of onset of acute ischemic stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468942/
https://www.ncbi.nlm.nih.gov/pubmed/32806540
http://dx.doi.org/10.3390/nu12082411
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