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Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell

Caffeine–a methylxanthine analogue of the purine bases adenine and guanine–is by far the most consumed neuro-stimulant, being the active principle of widely consumed beverages such as coffee, tea, hot chocolate, and cola. While the best-known action of caffeine is to prevent sleepiness by blocking t...

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Detalles Bibliográficos
Autores principales: Ruta, Lavinia Liliana, Farcasanu, Ileana Cornelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468979/
https://www.ncbi.nlm.nih.gov/pubmed/32823708
http://dx.doi.org/10.3390/nu12082440
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author Ruta, Lavinia Liliana
Farcasanu, Ileana Cornelia
author_facet Ruta, Lavinia Liliana
Farcasanu, Ileana Cornelia
author_sort Ruta, Lavinia Liliana
collection PubMed
description Caffeine–a methylxanthine analogue of the purine bases adenine and guanine–is by far the most consumed neuro-stimulant, being the active principle of widely consumed beverages such as coffee, tea, hot chocolate, and cola. While the best-known action of caffeine is to prevent sleepiness by blocking the adenosine receptors, caffeine exerts a pleiotropic effect on cells, which lead to the activation or inhibition of various cell integrity pathways. The aim of this review is to present the main studies set to investigate the effects of caffeine on cells using the model eukaryotic microorganism Saccharomyces cerevisiae, highlighting the caffeine synergy with external cell stressors, such as irradiation or exposure to various chemical hazards, including cigarette smoke or chemical carcinogens. The review also focuses on the importance of caffeine-related yeast phenotypes used to resolve molecular mechanisms involved in cell signaling through conserved pathways, such as target of rapamycin (TOR) signaling, Pkc1-Mpk1 mitogen activated protein kinase (MAPK) cascade, or Ras/cAMP protein kinase A (PKA) pathway.
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spelling pubmed-74689792020-09-04 Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell Ruta, Lavinia Liliana Farcasanu, Ileana Cornelia Nutrients Review Caffeine–a methylxanthine analogue of the purine bases adenine and guanine–is by far the most consumed neuro-stimulant, being the active principle of widely consumed beverages such as coffee, tea, hot chocolate, and cola. While the best-known action of caffeine is to prevent sleepiness by blocking the adenosine receptors, caffeine exerts a pleiotropic effect on cells, which lead to the activation or inhibition of various cell integrity pathways. The aim of this review is to present the main studies set to investigate the effects of caffeine on cells using the model eukaryotic microorganism Saccharomyces cerevisiae, highlighting the caffeine synergy with external cell stressors, such as irradiation or exposure to various chemical hazards, including cigarette smoke or chemical carcinogens. The review also focuses on the importance of caffeine-related yeast phenotypes used to resolve molecular mechanisms involved in cell signaling through conserved pathways, such as target of rapamycin (TOR) signaling, Pkc1-Mpk1 mitogen activated protein kinase (MAPK) cascade, or Ras/cAMP protein kinase A (PKA) pathway. MDPI 2020-08-13 /pmc/articles/PMC7468979/ /pubmed/32823708 http://dx.doi.org/10.3390/nu12082440 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ruta, Lavinia Liliana
Farcasanu, Ileana Cornelia
Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell
title Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell
title_full Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell
title_fullStr Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell
title_full_unstemmed Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell
title_short Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell
title_sort saccharomyces cerevisiae and caffeine implications on the eukaryotic cell
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468979/
https://www.ncbi.nlm.nih.gov/pubmed/32823708
http://dx.doi.org/10.3390/nu12082440
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