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Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell
Caffeine–a methylxanthine analogue of the purine bases adenine and guanine–is by far the most consumed neuro-stimulant, being the active principle of widely consumed beverages such as coffee, tea, hot chocolate, and cola. While the best-known action of caffeine is to prevent sleepiness by blocking t...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468979/ https://www.ncbi.nlm.nih.gov/pubmed/32823708 http://dx.doi.org/10.3390/nu12082440 |
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author | Ruta, Lavinia Liliana Farcasanu, Ileana Cornelia |
author_facet | Ruta, Lavinia Liliana Farcasanu, Ileana Cornelia |
author_sort | Ruta, Lavinia Liliana |
collection | PubMed |
description | Caffeine–a methylxanthine analogue of the purine bases adenine and guanine–is by far the most consumed neuro-stimulant, being the active principle of widely consumed beverages such as coffee, tea, hot chocolate, and cola. While the best-known action of caffeine is to prevent sleepiness by blocking the adenosine receptors, caffeine exerts a pleiotropic effect on cells, which lead to the activation or inhibition of various cell integrity pathways. The aim of this review is to present the main studies set to investigate the effects of caffeine on cells using the model eukaryotic microorganism Saccharomyces cerevisiae, highlighting the caffeine synergy with external cell stressors, such as irradiation or exposure to various chemical hazards, including cigarette smoke or chemical carcinogens. The review also focuses on the importance of caffeine-related yeast phenotypes used to resolve molecular mechanisms involved in cell signaling through conserved pathways, such as target of rapamycin (TOR) signaling, Pkc1-Mpk1 mitogen activated protein kinase (MAPK) cascade, or Ras/cAMP protein kinase A (PKA) pathway. |
format | Online Article Text |
id | pubmed-7468979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74689792020-09-04 Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell Ruta, Lavinia Liliana Farcasanu, Ileana Cornelia Nutrients Review Caffeine–a methylxanthine analogue of the purine bases adenine and guanine–is by far the most consumed neuro-stimulant, being the active principle of widely consumed beverages such as coffee, tea, hot chocolate, and cola. While the best-known action of caffeine is to prevent sleepiness by blocking the adenosine receptors, caffeine exerts a pleiotropic effect on cells, which lead to the activation or inhibition of various cell integrity pathways. The aim of this review is to present the main studies set to investigate the effects of caffeine on cells using the model eukaryotic microorganism Saccharomyces cerevisiae, highlighting the caffeine synergy with external cell stressors, such as irradiation or exposure to various chemical hazards, including cigarette smoke or chemical carcinogens. The review also focuses on the importance of caffeine-related yeast phenotypes used to resolve molecular mechanisms involved in cell signaling through conserved pathways, such as target of rapamycin (TOR) signaling, Pkc1-Mpk1 mitogen activated protein kinase (MAPK) cascade, or Ras/cAMP protein kinase A (PKA) pathway. MDPI 2020-08-13 /pmc/articles/PMC7468979/ /pubmed/32823708 http://dx.doi.org/10.3390/nu12082440 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ruta, Lavinia Liliana Farcasanu, Ileana Cornelia Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell |
title | Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell |
title_full | Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell |
title_fullStr | Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell |
title_full_unstemmed | Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell |
title_short | Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell |
title_sort | saccharomyces cerevisiae and caffeine implications on the eukaryotic cell |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468979/ https://www.ncbi.nlm.nih.gov/pubmed/32823708 http://dx.doi.org/10.3390/nu12082440 |
work_keys_str_mv | AT rutalavinialiliana saccharomycescerevisiaeandcaffeineimplicationsontheeukaryoticcell AT farcasanuileanacornelia saccharomycescerevisiaeandcaffeineimplicationsontheeukaryoticcell |