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Serum Iron and Risk of Diabetic Retinopathy

Background: Diabetic retinopathy (DR) is indicated as a major cause of blindness in the world. Emerging evidence supports the interaction of iron metabolism with diabetes. However, little research is available concerning the relationship between iron metabolism and DR. The intent of this paper is to...

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Autores principales: Chen, Ying-Jen, Chen, Jiann-Torng, Tai, Ming-Cheng, Liang, Chang-Min, Chen, Yuan-Yuei, Chen, Wei-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469039/
https://www.ncbi.nlm.nih.gov/pubmed/32751778
http://dx.doi.org/10.3390/nu12082297
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author Chen, Ying-Jen
Chen, Jiann-Torng
Tai, Ming-Cheng
Liang, Chang-Min
Chen, Yuan-Yuei
Chen, Wei-Liang
author_facet Chen, Ying-Jen
Chen, Jiann-Torng
Tai, Ming-Cheng
Liang, Chang-Min
Chen, Yuan-Yuei
Chen, Wei-Liang
author_sort Chen, Ying-Jen
collection PubMed
description Background: Diabetic retinopathy (DR) is indicated as a major cause of blindness in the world. Emerging evidence supports the interaction of iron metabolism with diabetes. However, little research is available concerning the relationship between iron metabolism and DR. The intent of this paper is to describe the correlation between serum iron and the occurrence of DR. Methods: A total of 5321 participants who underwent related examinations as part of the National Health and Nutrition Examination Survey (2005–2008) were included. DR was defined by the criteria of the Early Treatment for Diabetic Retinopathy Study based on nonmydriatic fundus photography. The cutoff point of serum iron for DR was explored by the receiver operating characteristics curve. The relationship of serum iron with the occurrence of DR was explored by multivariate logistic regression models. Results: Participants with DR had significantly lower serum iron than the control group. Serum iron was negatively correlated with the occurrence of DR after the adjustment of pertinent variables (an odds ratio (OR) of 0.995 (95% CI: 0.992–0.999)). After dividing serum iron into quartiles, the third quartile was associated with DR with an OR of 0.601 (95% CI: 0.418–0.863). Furthermore, the cutoff point of serum iron had an inverse relationship for the occurrence of DR with an OR of 0.766 (95% CI: 0.597–0.984). Conclusion: Serum iron has an inverse association with the occurrence of DR in diabetic adults. The assessment of serum iron levels might be a part of follow-up visits with diabetic patients.
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spelling pubmed-74690392020-09-04 Serum Iron and Risk of Diabetic Retinopathy Chen, Ying-Jen Chen, Jiann-Torng Tai, Ming-Cheng Liang, Chang-Min Chen, Yuan-Yuei Chen, Wei-Liang Nutrients Article Background: Diabetic retinopathy (DR) is indicated as a major cause of blindness in the world. Emerging evidence supports the interaction of iron metabolism with diabetes. However, little research is available concerning the relationship between iron metabolism and DR. The intent of this paper is to describe the correlation between serum iron and the occurrence of DR. Methods: A total of 5321 participants who underwent related examinations as part of the National Health and Nutrition Examination Survey (2005–2008) were included. DR was defined by the criteria of the Early Treatment for Diabetic Retinopathy Study based on nonmydriatic fundus photography. The cutoff point of serum iron for DR was explored by the receiver operating characteristics curve. The relationship of serum iron with the occurrence of DR was explored by multivariate logistic regression models. Results: Participants with DR had significantly lower serum iron than the control group. Serum iron was negatively correlated with the occurrence of DR after the adjustment of pertinent variables (an odds ratio (OR) of 0.995 (95% CI: 0.992–0.999)). After dividing serum iron into quartiles, the third quartile was associated with DR with an OR of 0.601 (95% CI: 0.418–0.863). Furthermore, the cutoff point of serum iron had an inverse relationship for the occurrence of DR with an OR of 0.766 (95% CI: 0.597–0.984). Conclusion: Serum iron has an inverse association with the occurrence of DR in diabetic adults. The assessment of serum iron levels might be a part of follow-up visits with diabetic patients. MDPI 2020-07-31 /pmc/articles/PMC7469039/ /pubmed/32751778 http://dx.doi.org/10.3390/nu12082297 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Ying-Jen
Chen, Jiann-Torng
Tai, Ming-Cheng
Liang, Chang-Min
Chen, Yuan-Yuei
Chen, Wei-Liang
Serum Iron and Risk of Diabetic Retinopathy
title Serum Iron and Risk of Diabetic Retinopathy
title_full Serum Iron and Risk of Diabetic Retinopathy
title_fullStr Serum Iron and Risk of Diabetic Retinopathy
title_full_unstemmed Serum Iron and Risk of Diabetic Retinopathy
title_short Serum Iron and Risk of Diabetic Retinopathy
title_sort serum iron and risk of diabetic retinopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469039/
https://www.ncbi.nlm.nih.gov/pubmed/32751778
http://dx.doi.org/10.3390/nu12082297
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