Cargando…

Anti-Obesity Effects of Macroalgae

Macroalgae have attracted great interest for their potential applications in nutraceutical and pharmaceutical industries as source of bioactive medicinal products and food ingredients. This review gathers data from in vitro and in vivo studies addressing the anti-obesity effects of macroalgae. Great...

Descripción completa

Detalles Bibliográficos
Autores principales: Gómez-Zorita, Saioa, González-Arceo, Maitane, Trepiana, Jenifer, Eseberri, Itziar, Fernández-Quintela, Alfredo, Milton-Laskibar, Iñaki, Aguirre, Leixuri, González, Marcela, Portillo, María P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469045/
https://www.ncbi.nlm.nih.gov/pubmed/32784488
http://dx.doi.org/10.3390/nu12082378
_version_ 1783578347247239168
author Gómez-Zorita, Saioa
González-Arceo, Maitane
Trepiana, Jenifer
Eseberri, Itziar
Fernández-Quintela, Alfredo
Milton-Laskibar, Iñaki
Aguirre, Leixuri
González, Marcela
Portillo, María P.
author_facet Gómez-Zorita, Saioa
González-Arceo, Maitane
Trepiana, Jenifer
Eseberri, Itziar
Fernández-Quintela, Alfredo
Milton-Laskibar, Iñaki
Aguirre, Leixuri
González, Marcela
Portillo, María P.
author_sort Gómez-Zorita, Saioa
collection PubMed
description Macroalgae have attracted great interest for their potential applications in nutraceutical and pharmaceutical industries as source of bioactive medicinal products and food ingredients. This review gathers data from in vitro and in vivo studies addressing the anti-obesity effects of macroalgae. Great consensus exists in all reported in vitro studies concerning the reduction induced by seaweed extracts in the expression of transcriptional factors controlling adipogenesis. In animals, macroalgae reduced body fat accumulation and prevented other obesity features, such as dyslipidemia, insulin resistance and fatty liver. These effects are not due to food intake reduction, since few studies have reported such event. Indeed, the effects on metabolic pathways in target tissues/organs seem to play a more relevant role. Macroalgae can reduce de novo lipogenesis, limiting fatty acid availability for triglyceride synthesis in white adipose tissue. This effect has been observed in both cell cultures and adipose tissue from animals treated with macroalgae extracts. In addition, increased fatty acid oxidation and thermogenic capacity, as well as a shift towards healthier gut microbiota composition may contribute to the body fat-lowering effect of macroalgae. Studies in humans are needed to determine whether macroalgae can represent a feasible tool to prevent and/or manage overweight and obesity.
format Online
Article
Text
id pubmed-7469045
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74690452020-09-04 Anti-Obesity Effects of Macroalgae Gómez-Zorita, Saioa González-Arceo, Maitane Trepiana, Jenifer Eseberri, Itziar Fernández-Quintela, Alfredo Milton-Laskibar, Iñaki Aguirre, Leixuri González, Marcela Portillo, María P. Nutrients Review Macroalgae have attracted great interest for their potential applications in nutraceutical and pharmaceutical industries as source of bioactive medicinal products and food ingredients. This review gathers data from in vitro and in vivo studies addressing the anti-obesity effects of macroalgae. Great consensus exists in all reported in vitro studies concerning the reduction induced by seaweed extracts in the expression of transcriptional factors controlling adipogenesis. In animals, macroalgae reduced body fat accumulation and prevented other obesity features, such as dyslipidemia, insulin resistance and fatty liver. These effects are not due to food intake reduction, since few studies have reported such event. Indeed, the effects on metabolic pathways in target tissues/organs seem to play a more relevant role. Macroalgae can reduce de novo lipogenesis, limiting fatty acid availability for triglyceride synthesis in white adipose tissue. This effect has been observed in both cell cultures and adipose tissue from animals treated with macroalgae extracts. In addition, increased fatty acid oxidation and thermogenic capacity, as well as a shift towards healthier gut microbiota composition may contribute to the body fat-lowering effect of macroalgae. Studies in humans are needed to determine whether macroalgae can represent a feasible tool to prevent and/or manage overweight and obesity. MDPI 2020-08-08 /pmc/articles/PMC7469045/ /pubmed/32784488 http://dx.doi.org/10.3390/nu12082378 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gómez-Zorita, Saioa
González-Arceo, Maitane
Trepiana, Jenifer
Eseberri, Itziar
Fernández-Quintela, Alfredo
Milton-Laskibar, Iñaki
Aguirre, Leixuri
González, Marcela
Portillo, María P.
Anti-Obesity Effects of Macroalgae
title Anti-Obesity Effects of Macroalgae
title_full Anti-Obesity Effects of Macroalgae
title_fullStr Anti-Obesity Effects of Macroalgae
title_full_unstemmed Anti-Obesity Effects of Macroalgae
title_short Anti-Obesity Effects of Macroalgae
title_sort anti-obesity effects of macroalgae
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469045/
https://www.ncbi.nlm.nih.gov/pubmed/32784488
http://dx.doi.org/10.3390/nu12082378
work_keys_str_mv AT gomezzoritasaioa antiobesityeffectsofmacroalgae
AT gonzalezarceomaitane antiobesityeffectsofmacroalgae
AT trepianajenifer antiobesityeffectsofmacroalgae
AT eseberriitziar antiobesityeffectsofmacroalgae
AT fernandezquintelaalfredo antiobesityeffectsofmacroalgae
AT miltonlaskibarinaki antiobesityeffectsofmacroalgae
AT aguirreleixuri antiobesityeffectsofmacroalgae
AT gonzalezmarcela antiobesityeffectsofmacroalgae
AT portillomariap antiobesityeffectsofmacroalgae