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A Pilot Study Examining Vitamin C Levels in Periodontal Patients

Background: Periodontal disease is the leading cause of tooth loss worldwide. Current periodontal treatment is limited by its dependency on patients learning and maintaining good dental habits, and repeated visits to oral health physicians. Vitamin C’s role in collagen synthesis and immune function...

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Autores principales: Munday, Molly-Rose, Rodricks, Rohan, Fitzpatrick, Michael, Flood, Victoria M., Gunton, Jenny E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469055/
https://www.ncbi.nlm.nih.gov/pubmed/32731485
http://dx.doi.org/10.3390/nu12082255
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author Munday, Molly-Rose
Rodricks, Rohan
Fitzpatrick, Michael
Flood, Victoria M.
Gunton, Jenny E.
author_facet Munday, Molly-Rose
Rodricks, Rohan
Fitzpatrick, Michael
Flood, Victoria M.
Gunton, Jenny E.
author_sort Munday, Molly-Rose
collection PubMed
description Background: Periodontal disease is the leading cause of tooth loss worldwide. Current periodontal treatment is limited by its dependency on patients learning and maintaining good dental habits, and repeated visits to oral health physicians. Vitamin C’s role in collagen synthesis and immune function makes it important in wound healing and possibly periodontal healing. Therefore, if some patients are deficient, this may worsen patient outcomes. Methods: Patients were invited to participate following assessment and treatment at the Westmead Centre of Oral Health Periodontic Clinic, regardless of current disease stage or treatment. Adults were eligible if they gave informed consent and had current periodontal disease. Study involvement consisted of periodontal assessment and care followed by an interview and measurement of serum vitamin C and C-reactive protein (CRP). Results: A total of 6 out of 20 patients had vitamin C levels less than the institutional normal range, of whom 2 had levels <11.4 μmol/L and one <28 μmol/L. Low vitamin C was associated with higher periodontal disease stage (p = 0.03). Elevated CRP was found in 2/3 of people with low vitamin C and CRP was negatively correlated with vitamin C (p < 0.01). Vitamin C did not correlate with patient-reported fruit or vegetable consumption, but high processed meat intake was associated with lower vitamin C. Conclusion: Although a small study, this rate of vitamin C deficiency in the periodontal clinic is clinically important and correlations with disease severity and CRP suggests biological importance. This warrants further studies to assess vitamin C and whether supplementation improves periodontal outcomes, particularly in deficient subjects.
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spelling pubmed-74690552020-09-04 A Pilot Study Examining Vitamin C Levels in Periodontal Patients Munday, Molly-Rose Rodricks, Rohan Fitzpatrick, Michael Flood, Victoria M. Gunton, Jenny E. Nutrients Article Background: Periodontal disease is the leading cause of tooth loss worldwide. Current periodontal treatment is limited by its dependency on patients learning and maintaining good dental habits, and repeated visits to oral health physicians. Vitamin C’s role in collagen synthesis and immune function makes it important in wound healing and possibly periodontal healing. Therefore, if some patients are deficient, this may worsen patient outcomes. Methods: Patients were invited to participate following assessment and treatment at the Westmead Centre of Oral Health Periodontic Clinic, regardless of current disease stage or treatment. Adults were eligible if they gave informed consent and had current periodontal disease. Study involvement consisted of periodontal assessment and care followed by an interview and measurement of serum vitamin C and C-reactive protein (CRP). Results: A total of 6 out of 20 patients had vitamin C levels less than the institutional normal range, of whom 2 had levels <11.4 μmol/L and one <28 μmol/L. Low vitamin C was associated with higher periodontal disease stage (p = 0.03). Elevated CRP was found in 2/3 of people with low vitamin C and CRP was negatively correlated with vitamin C (p < 0.01). Vitamin C did not correlate with patient-reported fruit or vegetable consumption, but high processed meat intake was associated with lower vitamin C. Conclusion: Although a small study, this rate of vitamin C deficiency in the periodontal clinic is clinically important and correlations with disease severity and CRP suggests biological importance. This warrants further studies to assess vitamin C and whether supplementation improves periodontal outcomes, particularly in deficient subjects. MDPI 2020-07-28 /pmc/articles/PMC7469055/ /pubmed/32731485 http://dx.doi.org/10.3390/nu12082255 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Munday, Molly-Rose
Rodricks, Rohan
Fitzpatrick, Michael
Flood, Victoria M.
Gunton, Jenny E.
A Pilot Study Examining Vitamin C Levels in Periodontal Patients
title A Pilot Study Examining Vitamin C Levels in Periodontal Patients
title_full A Pilot Study Examining Vitamin C Levels in Periodontal Patients
title_fullStr A Pilot Study Examining Vitamin C Levels in Periodontal Patients
title_full_unstemmed A Pilot Study Examining Vitamin C Levels in Periodontal Patients
title_short A Pilot Study Examining Vitamin C Levels in Periodontal Patients
title_sort pilot study examining vitamin c levels in periodontal patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469055/
https://www.ncbi.nlm.nih.gov/pubmed/32731485
http://dx.doi.org/10.3390/nu12082255
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