The relationship between TRAF6 and tumors

Tumor necrosis factor receptor (TNFR)-related factors (TRAFs) are important linker molecules in the tumor necrosis factor superfamily (TNFSF) and the Toll-like/interleukin-1 receptor (TLR/ILR) superfamily. There are seven members: TRAF1-TRAF7, among those members, tumor necrosis factor receptor-asso...

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Autores principales: Li, Jiaoduan, Liu, Nian, Tang, Ling, Yan, Bei, Chen, Xiang, Zhang, Jianglin, Peng, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469280/
https://www.ncbi.nlm.nih.gov/pubmed/32905356
http://dx.doi.org/10.1186/s12935-020-01517-z
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author Li, Jiaoduan
Liu, Nian
Tang, Ling
Yan, Bei
Chen, Xiang
Zhang, Jianglin
Peng, Cong
author_facet Li, Jiaoduan
Liu, Nian
Tang, Ling
Yan, Bei
Chen, Xiang
Zhang, Jianglin
Peng, Cong
author_sort Li, Jiaoduan
collection PubMed
description Tumor necrosis factor receptor (TNFR)-related factors (TRAFs) are important linker molecules in the tumor necrosis factor superfamily (TNFSF) and the Toll-like/interleukin-1 receptor (TLR/ILR) superfamily. There are seven members: TRAF1-TRAF7, among those members, tumor necrosis factor receptor-associated factor 6 (TRAF6) is upregulated in various tumors, which has been related to tumorigenesis and development. With the in-depth study of the relationship between TRAF6 and different types of tumors, TRAF6 has oncogenic characteristics involved in tumorigenesis, tumor development, invasion, and metastasis through various signaling pathways, therefore, targeting TRAF6 has provided a novel strategy for tumor treatment. This review summarizes and analyzes the role of TRAF6 in tumorigenesis and tumor development in combination with the current research on TRAF6 and tumors.
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spelling pubmed-74692802020-09-03 The relationship between TRAF6 and tumors Li, Jiaoduan Liu, Nian Tang, Ling Yan, Bei Chen, Xiang Zhang, Jianglin Peng, Cong Cancer Cell Int Review Tumor necrosis factor receptor (TNFR)-related factors (TRAFs) are important linker molecules in the tumor necrosis factor superfamily (TNFSF) and the Toll-like/interleukin-1 receptor (TLR/ILR) superfamily. There are seven members: TRAF1-TRAF7, among those members, tumor necrosis factor receptor-associated factor 6 (TRAF6) is upregulated in various tumors, which has been related to tumorigenesis and development. With the in-depth study of the relationship between TRAF6 and different types of tumors, TRAF6 has oncogenic characteristics involved in tumorigenesis, tumor development, invasion, and metastasis through various signaling pathways, therefore, targeting TRAF6 has provided a novel strategy for tumor treatment. This review summarizes and analyzes the role of TRAF6 in tumorigenesis and tumor development in combination with the current research on TRAF6 and tumors. BioMed Central 2020-09-03 /pmc/articles/PMC7469280/ /pubmed/32905356 http://dx.doi.org/10.1186/s12935-020-01517-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Li, Jiaoduan
Liu, Nian
Tang, Ling
Yan, Bei
Chen, Xiang
Zhang, Jianglin
Peng, Cong
The relationship between TRAF6 and tumors
title The relationship between TRAF6 and tumors
title_full The relationship between TRAF6 and tumors
title_fullStr The relationship between TRAF6 and tumors
title_full_unstemmed The relationship between TRAF6 and tumors
title_short The relationship between TRAF6 and tumors
title_sort relationship between traf6 and tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469280/
https://www.ncbi.nlm.nih.gov/pubmed/32905356
http://dx.doi.org/10.1186/s12935-020-01517-z
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