Immunotherapy with heat shock protein 96 to treat gliomas

Heat shock protein 96 (gp96) is a highly conserved protein in the endoplasmic reticulum. The functions of gp96 include promoting the oncogenesis and progression of glioma. In addition, tumor-derived gp96 can activate anti-tumor immune. Therefore, this protein was used to generate an anti-tumor vacci...

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Autores principales: Li, Chunzhao, Du, Yifei, Zhang, Yang, Ji, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469332/
https://www.ncbi.nlm.nih.gov/pubmed/32922959
http://dx.doi.org/10.1186/s41016-020-00211-3
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author Li, Chunzhao
Du, Yifei
Zhang, Yang
Ji, Nan
author_facet Li, Chunzhao
Du, Yifei
Zhang, Yang
Ji, Nan
author_sort Li, Chunzhao
collection PubMed
description Heat shock protein 96 (gp96) is a highly conserved protein in the endoplasmic reticulum. The functions of gp96 include promoting the oncogenesis and progression of glioma. In addition, tumor-derived gp96 can activate anti-tumor immune. Therefore, this protein was used to generate an anti-tumor vaccine and widely applied to glioma therapy. This review summarizes the mechanisms of gp96 in glioma oncogenesis and clinical trials of the gp96 tumor vaccine in glioma treatment.
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spelling pubmed-74693322020-09-10 Immunotherapy with heat shock protein 96 to treat gliomas Li, Chunzhao Du, Yifei Zhang, Yang Ji, Nan Chin Neurosurg J Review Heat shock protein 96 (gp96) is a highly conserved protein in the endoplasmic reticulum. The functions of gp96 include promoting the oncogenesis and progression of glioma. In addition, tumor-derived gp96 can activate anti-tumor immune. Therefore, this protein was used to generate an anti-tumor vaccine and widely applied to glioma therapy. This review summarizes the mechanisms of gp96 in glioma oncogenesis and clinical trials of the gp96 tumor vaccine in glioma treatment. BioMed Central 2020-09-03 /pmc/articles/PMC7469332/ /pubmed/32922959 http://dx.doi.org/10.1186/s41016-020-00211-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Li, Chunzhao
Du, Yifei
Zhang, Yang
Ji, Nan
Immunotherapy with heat shock protein 96 to treat gliomas
title Immunotherapy with heat shock protein 96 to treat gliomas
title_full Immunotherapy with heat shock protein 96 to treat gliomas
title_fullStr Immunotherapy with heat shock protein 96 to treat gliomas
title_full_unstemmed Immunotherapy with heat shock protein 96 to treat gliomas
title_short Immunotherapy with heat shock protein 96 to treat gliomas
title_sort immunotherapy with heat shock protein 96 to treat gliomas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469332/
https://www.ncbi.nlm.nih.gov/pubmed/32922959
http://dx.doi.org/10.1186/s41016-020-00211-3
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