Cargando…

Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease

BACKGROUND: Identifying and understanding the functional role of genetic risk factors for Alzheimer disease (AD) has been complicated by the variability of genetic influences across brain regions and confounding with age-related neurodegeneration. METHODS: A gene co-expression network was constructe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lancour, Daniel, Dupuis, Josée, Mayeux, Richard, Haines, Jonathan L., Pericak-Vance, Margaret A., Schellenberg, Gerard C., Crovella, Mark, Farrer, Lindsay A., Kasif, Simon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469336/ https://www.ncbi.nlm.nih.gov/pubmed/32878640 http://dx.doi.org/10.1186/s13195-020-00674-7

Ejemplares similares

One for all and all for One: Improving replication of genetic studies through network diffusion
por: Lancour, Daniel, et al.
Publicado: (2018)

Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease
por: Zhang, Xiaoling, et al.
Publicado: (2021)

CpG‐related SNPs in the MS4A region have a dose‐dependent effect on risk of late–onset Alzheimer disease
por: Ma, Yiyi, et al.
Publicado: (2019)

Large‐scale sequencing studies expand the known genetic architecture of Alzheimer's disease
por: Xue, Diane, et al.
Publicado: (2021)

Progranulin mutations in clinical and neuropathological Alzheimer's disease
por: Vardarajan, Badri N., et al.
Publicado: (2022)

Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease
por: Chung, Jaeyoon, et al.
Publicado: (2018)

Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease
por: Jun, Gyungah R., et al.
Publicado: (2022)

Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)
por: Reitz, C, et al.
Publicado: (2013)

An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease–related patterns
por: Jin, Bowen, et al.
Publicado: (2022)

Corrigendum: An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease–related patterns
por: Jin, Bowen, et al.
Publicado: (2022)

Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease
por: Beecham, Gary W., et al.
Publicado: (2018)

ABCA7 frameshift deletion associated with Alzheimer disease in African Americans
por: Cukier, Holly N., et al.
Publicado: (2016)

Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry
por: Patel, Devanshi, et al.
Publicado: (2019)

Whole genome sequencing of Caribbean Hispanic families with late‐onset Alzheimer's disease
por: Vardarajan, Badri N., et al.
Publicado: (2018)

Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease
por: Kohli, Martin A., et al.
Publicado: (2016)

Targeted Sequencing of Alzheimer Disease Genes in African Americans Implicates Novel Risk Variants
por: Logue, Mark W., et al.
Publicado: (2018)

Caspase-8, association with Alzheimer’s Disease and functional analysis of rare variants
por: Rehker, Jan, et al.
Publicado: (2017)

The Alzheimer's Disease Sequencing Project: Study design and sample selection
por: Beecham, Gary W., et al.
Publicado: (2017)

Association of Common and Rare Variants with Alzheimer’s Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer’s Disease Sequencing Project
por: Lee, Wan-Ping, et al.
Publicado: (2023)

Comparison of methods for multivariate gene-based association tests for complex diseases using common variants
por: Chung, Jaeyoon, et al.
Publicado: (2019)

F-box/LRR-repeat protein 7 is genetically associated with Alzheimer’s disease
por: Tosto, Giuseppe, et al.
Publicado: (2015)

Exome Sequencing of Extended Families with Alzheimer’s Disease Identifies Novel Genes Implicated in Cell Immunity and Neuronal Function
por: Cukier, HN, et al.
Publicado: (2017)

Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels
por: Allen, Mariet, et al.
Publicado: (2014)

The Impact of the Human Genome Project on Complex Disease
por: Cooke Bailey, Jessica N., et al.
Publicado: (2014)

The National Institute on Aging Late‐Onset Alzheimer's Disease Family Based Study: A resource for genetic discovery
por: Reyes‐Dumeyer, Dolly, et al.
Publicado: (2022)

SORL1 mutations in early- and late-onset Alzheimer disease
por: Cuccaro, Michael L., et al.
Publicado: (2016)

Examination of Candidate Exonic Variants for Association to Alzheimer Disease in the Amish
por: D’Aoust, Laura N., et al.
Publicado: (2015)

Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease
por: Qiao, Min, et al.
Publicado: (2023)

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
por: Desikan, Rahul S., et al.
Publicado: (2017)

Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations
por: Rajabli, Farid, et al.
Publicado: (2018)

Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias
por: Beecham, Gary W., et al.
Publicado: (2014)

Missense variant in TREML2 protects against Alzheimer's disease
por: Benitez, Bruno A., et al.
Publicado: (2014)

Neuropathological lesions and their contribution to dementia and cognitive impairment in a heterogeneous clinical population
por: Godrich, Dana, et al.
Publicado: (2022)

Use of local genetic ancestry to assess TOMM40-523′ and risk for Alzheimer disease
por: Bussies, Parker L., et al.
Publicado: (2020)

Seeing the forest for the trees: using the Gene Ontology to restructure hierarchical clustering
por: Dotan-Cohen, Dikla, et al.
Publicado: (2009)

Regional Differential Genetic Response of Human Articular Cartilage to Impact Injury
por: Vernon, Lauren L., et al.
Publicado: (2015)

Genetic overlap between Alzheimer’s disease and Parkinson’s disease at the MAPT locus
por: Desikan, Rahul S., et al.
Publicado: (2015)

Genomic functional annotation using co-evolution profiles of gene clusters
por: Zheng, Yu, et al.
Publicado: (2002)

Genome-wide association study of Alzheimer's disease
por: Kamboh, M I, et al.
Publicado: (2012)

Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities
por: Naj, Adam C., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_oo0d6ipej0ot1ujakf40vcppa5