Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML

BACKGROUND: The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early drivers of myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), with STAG2 the most frequently mutated complex member....

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Detalles Bibliográficos
Autores principales: Smith, James S., Lappin, Katrina M., Craig, Stephanie G., Liberante, Fabio G., Crean, Clare M., McDade, Simon S., Thompson, Alexander, Mills, Ken I., Savage, Kienan I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469420/
https://www.ncbi.nlm.nih.gov/pubmed/32883299
http://dx.doi.org/10.1186/s12967-020-02500-y

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