Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?

While genomic instability and mitochondrial homeostasis are integral for cancer progression, how these two hallmarks interact remains poorly understood. Here, we reflect on the dialogue between chromatin-based genomic instability and impairment of mitochondrial function and depict the importance of...

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Autores principales: Liu, Yue, Li, Haojian, Zimmerman, Susan E., Weyemi, Urbain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469531/
https://www.ncbi.nlm.nih.gov/pubmed/32944631
http://dx.doi.org/10.1080/23723556.2020.1771959
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author Liu, Yue
Li, Haojian
Zimmerman, Susan E.
Weyemi, Urbain
author_facet Liu, Yue
Li, Haojian
Zimmerman, Susan E.
Weyemi, Urbain
author_sort Liu, Yue
collection PubMed
description While genomic instability and mitochondrial homeostasis are integral for cancer progression, how these two hallmarks interact remains poorly understood. Here, we reflect on the dialogue between chromatin-based genomic instability and impairment of mitochondrial function and depict the importance of this interaction in cancer progression to metastasis.
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spelling pubmed-74695312020-09-28 Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say? Liu, Yue Li, Haojian Zimmerman, Susan E. Weyemi, Urbain Mol Cell Oncol Author's Views While genomic instability and mitochondrial homeostasis are integral for cancer progression, how these two hallmarks interact remains poorly understood. Here, we reflect on the dialogue between chromatin-based genomic instability and impairment of mitochondrial function and depict the importance of this interaction in cancer progression to metastasis. Taylor & Francis 2020-07-13 /pmc/articles/PMC7469531/ /pubmed/32944631 http://dx.doi.org/10.1080/23723556.2020.1771959 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Liu, Yue
Li, Haojian
Zimmerman, Susan E.
Weyemi, Urbain
Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?
title Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?
title_full Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?
title_fullStr Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?
title_full_unstemmed Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?
title_short Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?
title_sort genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469531/
https://www.ncbi.nlm.nih.gov/pubmed/32944631
http://dx.doi.org/10.1080/23723556.2020.1771959
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