Survival of the resilient: Mechano-adaptation of circulating tumor cells to fluid shear stress

During metastasis, cancer cells traverse the circulation to reach distant organs. Conventionally, this journey has been regarded as mechanically destructive to circulating tumor cells from solid tissues. We have recently shown that cancer cells from diverse tissues actively resist destruction by flu...

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Detalles Bibliográficos
Autores principales: Moose, Devon L., Henry, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469561/
https://www.ncbi.nlm.nih.gov/pubmed/32944626
http://dx.doi.org/10.1080/23723556.2020.1766338
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author Moose, Devon L.
Henry, Michael D.
author_facet Moose, Devon L.
Henry, Michael D.
author_sort Moose, Devon L.
collection PubMed
description During metastasis, cancer cells traverse the circulation to reach distant organs. Conventionally, this journey has been regarded as mechanically destructive to circulating tumor cells from solid tissues. We have recently shown that cancer cells from diverse tissues actively resist destruction by fluid shear stress through a mechano-adaptive RhoA-actomyosin mechanism.
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spelling pubmed-74695612020-09-28 Survival of the resilient: Mechano-adaptation of circulating tumor cells to fluid shear stress Moose, Devon L. Henry, Michael D. Mol Cell Oncol Author’s Views During metastasis, cancer cells traverse the circulation to reach distant organs. Conventionally, this journey has been regarded as mechanically destructive to circulating tumor cells from solid tissues. We have recently shown that cancer cells from diverse tissues actively resist destruction by fluid shear stress through a mechano-adaptive RhoA-actomyosin mechanism. Taylor & Francis 2020-05-21 /pmc/articles/PMC7469561/ /pubmed/32944626 http://dx.doi.org/10.1080/23723556.2020.1766338 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Moose, Devon L.
Henry, Michael D.
Survival of the resilient: Mechano-adaptation of circulating tumor cells to fluid shear stress
title Survival of the resilient: Mechano-adaptation of circulating tumor cells to fluid shear stress
title_full Survival of the resilient: Mechano-adaptation of circulating tumor cells to fluid shear stress
title_fullStr Survival of the resilient: Mechano-adaptation of circulating tumor cells to fluid shear stress
title_full_unstemmed Survival of the resilient: Mechano-adaptation of circulating tumor cells to fluid shear stress
title_short Survival of the resilient: Mechano-adaptation of circulating tumor cells to fluid shear stress
title_sort survival of the resilient: mechano-adaptation of circulating tumor cells to fluid shear stress
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469561/
https://www.ncbi.nlm.nih.gov/pubmed/32944626
http://dx.doi.org/10.1080/23723556.2020.1766338
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