Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye

Renal medullary carcinoma (RMC) is a lethal disease that predominantly afflicts young individuals with sickle cell trait. Our recently reported molecular profiling of primary untreated RMC tissues elucidated distinct genomic and immune hallmarks of RMC, and identified MYC-induced replication stress...

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Detalles Bibliográficos
Autores principales: Msaouel, Pavlos, Walker, Cheryl L., Genovese, Giannicola, Tannir, Nizar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469578/
https://www.ncbi.nlm.nih.gov/pubmed/32944636
http://dx.doi.org/10.1080/23723556.2020.1777060
Descripción
Sumario:Renal medullary carcinoma (RMC) is a lethal disease that predominantly afflicts young individuals with sickle cell trait. Our recently reported molecular profiling of primary untreated RMC tissues elucidated distinct genomic and immune hallmarks of RMC, and identified MYC-induced replication stress as a targetable vulnerability for this disease.

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