Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye

Renal medullary carcinoma (RMC) is a lethal disease that predominantly afflicts young individuals with sickle cell trait. Our recently reported molecular profiling of primary untreated RMC tissues elucidated distinct genomic and immune hallmarks of RMC, and identified MYC-induced replication stress...

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Autores principales: Msaouel, Pavlos, Walker, Cheryl L., Genovese, Giannicola, Tannir, Nizar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469578/
https://www.ncbi.nlm.nih.gov/pubmed/32944636
http://dx.doi.org/10.1080/23723556.2020.1777060
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author Msaouel, Pavlos
Walker, Cheryl L.
Genovese, Giannicola
Tannir, Nizar M.
author_facet Msaouel, Pavlos
Walker, Cheryl L.
Genovese, Giannicola
Tannir, Nizar M.
author_sort Msaouel, Pavlos
collection PubMed
description Renal medullary carcinoma (RMC) is a lethal disease that predominantly afflicts young individuals with sickle cell trait. Our recently reported molecular profiling of primary untreated RMC tissues elucidated distinct genomic and immune hallmarks of RMC, and identified MYC-induced replication stress as a targetable vulnerability for this disease.
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spelling pubmed-74695782020-09-28 Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye Msaouel, Pavlos Walker, Cheryl L. Genovese, Giannicola Tannir, Nizar M. Mol Cell Oncol Author's Views Renal medullary carcinoma (RMC) is a lethal disease that predominantly afflicts young individuals with sickle cell trait. Our recently reported molecular profiling of primary untreated RMC tissues elucidated distinct genomic and immune hallmarks of RMC, and identified MYC-induced replication stress as a targetable vulnerability for this disease. Taylor & Francis 2020-06-23 /pmc/articles/PMC7469578/ /pubmed/32944636 http://dx.doi.org/10.1080/23723556.2020.1777060 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Msaouel, Pavlos
Walker, Cheryl L.
Genovese, Giannicola
Tannir, Nizar M.
Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye
title Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye
title_full Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye
title_fullStr Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye
title_full_unstemmed Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye
title_short Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye
title_sort molecular hallmarks of renal medullary carcinoma: more to c-myc than meets the eye
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469578/
https://www.ncbi.nlm.nih.gov/pubmed/32944636
http://dx.doi.org/10.1080/23723556.2020.1777060
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