Synthesis of Chromeno[4,3-b]pyrrol-4(1H)-ones through a Multicomponent Reaction and Cyclization Strategy

[Image: see text] A novel three-component reaction of 2-oxo-2H-chromene-3-carbaldehydes with isocyanides and anilines was developed for one-pot assembly of biologically intriguing chromeno[4,3-b]pyrrol-4(1H)-ones, which can also be transferred into diverse polycyclic fused scaffolds through further...

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Autores principales: Lai, Xiangfeng, Che, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469652/
https://www.ncbi.nlm.nih.gov/pubmed/32905458
http://dx.doi.org/10.1021/acsomega.0c03589
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author Lai, Xiangfeng
Che, Chao
author_facet Lai, Xiangfeng
Che, Chao
author_sort Lai, Xiangfeng
collection PubMed
description [Image: see text] A novel three-component reaction of 2-oxo-2H-chromene-3-carbaldehydes with isocyanides and anilines was developed for one-pot assembly of biologically intriguing chromeno[4,3-b]pyrrol-4(1H)-ones, which can also be transferred into diverse polycyclic fused scaffolds through further synthetic manipulations. The described method tolerates a broad substrate scope and proceeds in moderate to good yield via a sequential multicomponent reaction and intramolecular Michael cyclization.
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spelling pubmed-74696522020-09-04 Synthesis of Chromeno[4,3-b]pyrrol-4(1H)-ones through a Multicomponent Reaction and Cyclization Strategy Lai, Xiangfeng Che, Chao ACS Omega [Image: see text] A novel three-component reaction of 2-oxo-2H-chromene-3-carbaldehydes with isocyanides and anilines was developed for one-pot assembly of biologically intriguing chromeno[4,3-b]pyrrol-4(1H)-ones, which can also be transferred into diverse polycyclic fused scaffolds through further synthetic manipulations. The described method tolerates a broad substrate scope and proceeds in moderate to good yield via a sequential multicomponent reaction and intramolecular Michael cyclization. American Chemical Society 2020-08-19 /pmc/articles/PMC7469652/ /pubmed/32905458 http://dx.doi.org/10.1021/acsomega.0c03589 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Lai, Xiangfeng
Che, Chao
Synthesis of Chromeno[4,3-b]pyrrol-4(1H)-ones through a Multicomponent Reaction and Cyclization Strategy
title Synthesis of Chromeno[4,3-b]pyrrol-4(1H)-ones through a Multicomponent Reaction and Cyclization Strategy
title_full Synthesis of Chromeno[4,3-b]pyrrol-4(1H)-ones through a Multicomponent Reaction and Cyclization Strategy
title_fullStr Synthesis of Chromeno[4,3-b]pyrrol-4(1H)-ones through a Multicomponent Reaction and Cyclization Strategy
title_full_unstemmed Synthesis of Chromeno[4,3-b]pyrrol-4(1H)-ones through a Multicomponent Reaction and Cyclization Strategy
title_short Synthesis of Chromeno[4,3-b]pyrrol-4(1H)-ones through a Multicomponent Reaction and Cyclization Strategy
title_sort synthesis of chromeno[4,3-b]pyrrol-4(1h)-ones through a multicomponent reaction and cyclization strategy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469652/
https://www.ncbi.nlm.nih.gov/pubmed/32905458
http://dx.doi.org/10.1021/acsomega.0c03589
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AT chechao synthesisofchromeno43bpyrrol41honesthroughamulticomponentreactionandcyclizationstrategy

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