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Mitochondrial Function in Hereditary Spastic Paraplegia: Deficits in SPG7 but Not SPAST Patient-Derived Stem Cells
Mutations in SPG7 and SPAST are common causes of hereditary spastic paraplegia (HSP). While some SPG7 mutations cause paraplegin deficiency, other SPG7 mutations cause increased paraplegin expression. Mitochondrial function has been studied in models that are paraplegin-deficient (human, mouse, and...
Autores principales: | Wali, Gautam, Kumar, Kishore Raj, Liyanage, Erandhi, Davis, Ryan L., Mackay-Sim, Alan, Sue, Carolyn M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469654/ https://www.ncbi.nlm.nih.gov/pubmed/32973427 http://dx.doi.org/10.3389/fnins.2020.00820 |
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