PathSTORM: a road to early cancer detection

Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive st...

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Detalles Bibliográficos
Autores principales: Troy, Kris, Liu, Yang, Hainer, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469673/
https://www.ncbi.nlm.nih.gov/pubmed/32944634
http://dx.doi.org/10.1080/23723556.2020.1776086
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author Troy, Kris
Liu, Yang
Hainer, Sarah J.
author_facet Troy, Kris
Liu, Yang
Hainer, Sarah J.
author_sort Troy, Kris
collection PubMed
description Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.
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spelling pubmed-74696732020-09-28 PathSTORM: a road to early cancer detection Troy, Kris Liu, Yang Hainer, Sarah J. Mol Cell Oncol Commentary Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology. Taylor & Francis 2020-06-21 /pmc/articles/PMC7469673/ /pubmed/32944634 http://dx.doi.org/10.1080/23723556.2020.1776086 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Troy, Kris
Liu, Yang
Hainer, Sarah J.
PathSTORM: a road to early cancer detection
title PathSTORM: a road to early cancer detection
title_full PathSTORM: a road to early cancer detection
title_fullStr PathSTORM: a road to early cancer detection
title_full_unstemmed PathSTORM: a road to early cancer detection
title_short PathSTORM: a road to early cancer detection
title_sort pathstorm: a road to early cancer detection
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469673/
https://www.ncbi.nlm.nih.gov/pubmed/32944634
http://dx.doi.org/10.1080/23723556.2020.1776086
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