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Targeted RNA Knockdown by a Type III CRISPR-Cas Complex in Zebrafish

RNA interference is a powerful experimental tool for RNA knockdown, but not all organisms are amenable. Here, we provide a proof of principle demonstration that a type III Csm effector complex can be used for programmable mRNA transcript degradation in eukaryotes. In zebrafish, Streptococcus thermop...

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Detalles Bibliográficos
Autores principales:	Fricke, Thomas, Smalakyte, Dalia, Lapinski, Maciej, Pateria, Abhishek, Weige, Charles, Pastor, Michal, Kolano, Agnieszka, Winata, Cecilia, Siksnys, Virginijus, Tamulaitis, Gintautas, Bochtler, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469701/ https://www.ncbi.nlm.nih.gov/pubmed/32833532 http://dx.doi.org/10.1089/crispr.2020.0032

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