Cargando…
Effect of neoadjuvant chemotherapy followed by surgery for FIGO stage I–II cervical cancer: a meta-analysis
OBJECTIVE: In this meta-analysis, we aimed to evaluate the oncological outcomes of preoperative neoadjuvant chemotherapy followed by radical surgery compared with radical surgery alone for treatment of International Federation of Gynecology and Obstetrics (FIGO) stage I–II cervical cancer. METHOD: W...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469733/ https://www.ncbi.nlm.nih.gov/pubmed/32867558 http://dx.doi.org/10.1177/0300060520945507 |
_version_ | 1783578453408219136 |
---|---|
author | Yang, Shu-Li Chen, Ling He, Yue Zhao, Hui Wu, Yu-Mei |
author_facet | Yang, Shu-Li Chen, Ling He, Yue Zhao, Hui Wu, Yu-Mei |
author_sort | Yang, Shu-Li |
collection | PubMed |
description | OBJECTIVE: In this meta-analysis, we aimed to evaluate the oncological outcomes of preoperative neoadjuvant chemotherapy followed by radical surgery compared with radical surgery alone for treatment of International Federation of Gynecology and Obstetrics (FIGO) stage I–II cervical cancer. METHOD: We searched for studies comparing the safety and efficacy of neoadjuvant chemotherapy plus surgery versus surgery alone in treatment outcomes of locally advanced cervical cancer. Meta-analysis was used to calculate the pooled odds ratios with corresponding 95% confidence intervals (CI). RESULTS: Sixteen studies were included in our analysis. Pooled analysis of overall survival rate [odds ratio (OR) = 1.09, 95% CI: 0.83–1.43] and progression-free survival rate (OR = 1.10, 95% CI: 0.77–1.57) showed that preoperative neoadjuvant chemotherapy did not have a benefit compared with surgery alone in terms of survival rates. The pooled results for postoperative parameters indicated that preoperative neoadjuvant chemotherapy followed by radical surgery was associated with a high rate of vascular space involvement (OR = 0.25, 95% CI: 0.17–0.35) and parametrial infiltration (OR = 0.60, 95% CI: 0.45–0.79). CONCLUSIONS: This meta-analysis indicated that surgery following neoadjuvant chemotherapy for FIGO stage I–II cervical cancer and surgery alone had similar oncological outcomes. |
format | Online Article Text |
id | pubmed-7469733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-74697332020-09-16 Effect of neoadjuvant chemotherapy followed by surgery for FIGO stage I–II cervical cancer: a meta-analysis Yang, Shu-Li Chen, Ling He, Yue Zhao, Hui Wu, Yu-Mei J Int Med Res Meta Analysis OBJECTIVE: In this meta-analysis, we aimed to evaluate the oncological outcomes of preoperative neoadjuvant chemotherapy followed by radical surgery compared with radical surgery alone for treatment of International Federation of Gynecology and Obstetrics (FIGO) stage I–II cervical cancer. METHOD: We searched for studies comparing the safety and efficacy of neoadjuvant chemotherapy plus surgery versus surgery alone in treatment outcomes of locally advanced cervical cancer. Meta-analysis was used to calculate the pooled odds ratios with corresponding 95% confidence intervals (CI). RESULTS: Sixteen studies were included in our analysis. Pooled analysis of overall survival rate [odds ratio (OR) = 1.09, 95% CI: 0.83–1.43] and progression-free survival rate (OR = 1.10, 95% CI: 0.77–1.57) showed that preoperative neoadjuvant chemotherapy did not have a benefit compared with surgery alone in terms of survival rates. The pooled results for postoperative parameters indicated that preoperative neoadjuvant chemotherapy followed by radical surgery was associated with a high rate of vascular space involvement (OR = 0.25, 95% CI: 0.17–0.35) and parametrial infiltration (OR = 0.60, 95% CI: 0.45–0.79). CONCLUSIONS: This meta-analysis indicated that surgery following neoadjuvant chemotherapy for FIGO stage I–II cervical cancer and surgery alone had similar oncological outcomes. SAGE Publications 2020-08-31 /pmc/articles/PMC7469733/ /pubmed/32867558 http://dx.doi.org/10.1177/0300060520945507 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Meta Analysis Yang, Shu-Li Chen, Ling He, Yue Zhao, Hui Wu, Yu-Mei Effect of neoadjuvant chemotherapy followed by surgery for FIGO stage I–II cervical cancer: a meta-analysis |
title | Effect of neoadjuvant chemotherapy followed by surgery for FIGO stage I–II cervical cancer: a meta-analysis |
title_full | Effect of neoadjuvant chemotherapy followed by surgery for FIGO stage I–II cervical cancer: a meta-analysis |
title_fullStr | Effect of neoadjuvant chemotherapy followed by surgery for FIGO stage I–II cervical cancer: a meta-analysis |
title_full_unstemmed | Effect of neoadjuvant chemotherapy followed by surgery for FIGO stage I–II cervical cancer: a meta-analysis |
title_short | Effect of neoadjuvant chemotherapy followed by surgery for FIGO stage I–II cervical cancer: a meta-analysis |
title_sort | effect of neoadjuvant chemotherapy followed by surgery for figo stage i–ii cervical cancer: a meta-analysis |
topic | Meta Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469733/ https://www.ncbi.nlm.nih.gov/pubmed/32867558 http://dx.doi.org/10.1177/0300060520945507 |
work_keys_str_mv | AT yangshuli effectofneoadjuvantchemotherapyfollowedbysurgeryforfigostageiiicervicalcancerametaanalysis AT chenling effectofneoadjuvantchemotherapyfollowedbysurgeryforfigostageiiicervicalcancerametaanalysis AT heyue effectofneoadjuvantchemotherapyfollowedbysurgeryforfigostageiiicervicalcancerametaanalysis AT zhaohui effectofneoadjuvantchemotherapyfollowedbysurgeryforfigostageiiicervicalcancerametaanalysis AT wuyumei effectofneoadjuvantchemotherapyfollowedbysurgeryforfigostageiiicervicalcancerametaanalysis |