Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis

INTRODUCTION: We report a rare case of renal cell carcinoma with vaginal metastasis that recurred with rapid progression and was resistant to sunitinib and nivolumab. CASE PRESENTATION: A 68‐year‐old woman presented with renal cell carcinoma and vaginal metastasis. Multiple lung metastasis appeared...

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Autores principales: Hisano, Mizuki, Kato, Renpei, Itamochi, Hiroaki, Matsuura, Tomohiko, Maekawa, Shigekatsu, Kato, Yoichiro, Kanehira, Mitsugu, Takata, Ryo, Baba, Tsukasa, Obara, Wataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469809/
https://www.ncbi.nlm.nih.gov/pubmed/32914070
http://dx.doi.org/10.1002/iju5.12179
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author Hisano, Mizuki
Kato, Renpei
Itamochi, Hiroaki
Matsuura, Tomohiko
Maekawa, Shigekatsu
Kato, Yoichiro
Kanehira, Mitsugu
Takata, Ryo
Baba, Tsukasa
Obara, Wataru
author_facet Hisano, Mizuki
Kato, Renpei
Itamochi, Hiroaki
Matsuura, Tomohiko
Maekawa, Shigekatsu
Kato, Yoichiro
Kanehira, Mitsugu
Takata, Ryo
Baba, Tsukasa
Obara, Wataru
author_sort Hisano, Mizuki
collection PubMed
description INTRODUCTION: We report a rare case of renal cell carcinoma with vaginal metastasis that recurred with rapid progression and was resistant to sunitinib and nivolumab. CASE PRESENTATION: A 68‐year‐old woman presented with renal cell carcinoma and vaginal metastasis. Multiple lung metastasis appeared 3 months after simultaneous radical nephrectomy and hysterectomy with vaginal resection. Despite the treatment with sunitinib and nivolumab, the patient died 7 months after surgery. Immunohistochemical staining of primary and metastatic tumor specimens was CD8 and programmed death ligand‐1 negative. CONCLUSION: Although vaginal metastasis of renal cell carcinoma is rare, lack of CD8 and programmed death ligand‐1 expression may cause nivolumab resistance and may be useful markers in patients with metastatic renal cell carcinoma.
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spelling pubmed-74698092020-09-09 Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis Hisano, Mizuki Kato, Renpei Itamochi, Hiroaki Matsuura, Tomohiko Maekawa, Shigekatsu Kato, Yoichiro Kanehira, Mitsugu Takata, Ryo Baba, Tsukasa Obara, Wataru IJU Case Rep Case Reports INTRODUCTION: We report a rare case of renal cell carcinoma with vaginal metastasis that recurred with rapid progression and was resistant to sunitinib and nivolumab. CASE PRESENTATION: A 68‐year‐old woman presented with renal cell carcinoma and vaginal metastasis. Multiple lung metastasis appeared 3 months after simultaneous radical nephrectomy and hysterectomy with vaginal resection. Despite the treatment with sunitinib and nivolumab, the patient died 7 months after surgery. Immunohistochemical staining of primary and metastatic tumor specimens was CD8 and programmed death ligand‐1 negative. CONCLUSION: Although vaginal metastasis of renal cell carcinoma is rare, lack of CD8 and programmed death ligand‐1 expression may cause nivolumab resistance and may be useful markers in patients with metastatic renal cell carcinoma. John Wiley and Sons Inc. 2020-07-07 /pmc/articles/PMC7469809/ /pubmed/32914070 http://dx.doi.org/10.1002/iju5.12179 Text en © 2020 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Hisano, Mizuki
Kato, Renpei
Itamochi, Hiroaki
Matsuura, Tomohiko
Maekawa, Shigekatsu
Kato, Yoichiro
Kanehira, Mitsugu
Takata, Ryo
Baba, Tsukasa
Obara, Wataru
Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis
title Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis
title_full Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis
title_fullStr Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis
title_full_unstemmed Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis
title_short Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis
title_sort rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469809/
https://www.ncbi.nlm.nih.gov/pubmed/32914070
http://dx.doi.org/10.1002/iju5.12179
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