Methylmercury toxic mechanism related to protein degradation and chemokine transcription

Methylmercury is an environmental pollutant that causes neurotoxicity. Recent studies have reported that the ubiquitin-proteasome system is involved in defense against methylmercury toxicity through the degradation of proteins synthesizing the pyruvate. Mitochondrial accumulation of pyruvate can enh...

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Autores principales: Lee, Jin-Yong, Hwang, Gi-Wook, Naganuma, Akira, Satoh, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469908/
https://www.ncbi.nlm.nih.gov/pubmed/32680455
http://dx.doi.org/10.1186/s12199-020-00868-3
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author Lee, Jin-Yong
Hwang, Gi-Wook
Naganuma, Akira
Satoh, Masahiko
author_facet Lee, Jin-Yong
Hwang, Gi-Wook
Naganuma, Akira
Satoh, Masahiko
author_sort Lee, Jin-Yong
collection PubMed
description Methylmercury is an environmental pollutant that causes neurotoxicity. Recent studies have reported that the ubiquitin-proteasome system is involved in defense against methylmercury toxicity through the degradation of proteins synthesizing the pyruvate. Mitochondrial accumulation of pyruvate can enhance methylmercury toxicity. In addition, methylmercury exposure induces several immune-related chemokines, specifically in the brain, and may cause neurotoxicity. This summary highlights several molecular mechanisms of methylmercury-induced neurotoxicity.
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spelling pubmed-74699082020-09-08 Methylmercury toxic mechanism related to protein degradation and chemokine transcription Lee, Jin-Yong Hwang, Gi-Wook Naganuma, Akira Satoh, Masahiko Environ Health Prev Med Review Article Methylmercury is an environmental pollutant that causes neurotoxicity. Recent studies have reported that the ubiquitin-proteasome system is involved in defense against methylmercury toxicity through the degradation of proteins synthesizing the pyruvate. Mitochondrial accumulation of pyruvate can enhance methylmercury toxicity. In addition, methylmercury exposure induces several immune-related chemokines, specifically in the brain, and may cause neurotoxicity. This summary highlights several molecular mechanisms of methylmercury-induced neurotoxicity. BioMed Central 2020-07-17 2020 /pmc/articles/PMC7469908/ /pubmed/32680455 http://dx.doi.org/10.1186/s12199-020-00868-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review Article
Lee, Jin-Yong
Hwang, Gi-Wook
Naganuma, Akira
Satoh, Masahiko
Methylmercury toxic mechanism related to protein degradation and chemokine transcription
title Methylmercury toxic mechanism related to protein degradation and chemokine transcription
title_full Methylmercury toxic mechanism related to protein degradation and chemokine transcription
title_fullStr Methylmercury toxic mechanism related to protein degradation and chemokine transcription
title_full_unstemmed Methylmercury toxic mechanism related to protein degradation and chemokine transcription
title_short Methylmercury toxic mechanism related to protein degradation and chemokine transcription
title_sort methylmercury toxic mechanism related to protein degradation and chemokine transcription
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469908/
https://www.ncbi.nlm.nih.gov/pubmed/32680455
http://dx.doi.org/10.1186/s12199-020-00868-3
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