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Controversies in the Treatment of Peripheral T-cell Lymphoma

Peripheral T-cell lymphomas are a heterogeneous group of rare diseases with an aggressive behavior and dismal prognosis. Their classification is complex and still evolving, and several biomolecular markers now help refine the prognosis of specific disease entities, although still have limited impact...

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Detalles Bibliográficos
Autores principales: Bachy, Emmanuel, Broccoli, Alessandro, Dearden, Claire, de Leval, Laurence, Gaulard, Philippe, Koch, Raphael, Morschhauser, Franck, Trümper, Lorenz, Zinzani, Pier Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469987/
https://www.ncbi.nlm.nih.gov/pubmed/33062943
http://dx.doi.org/10.1097/HS9.0000000000000461
Descripción
Sumario:Peripheral T-cell lymphomas are a heterogeneous group of rare diseases with an aggressive behavior and dismal prognosis. Their classification is complex and still evolving, and several biomolecular markers now help refine the prognosis of specific disease entities, although still have limited impact in tailoring the treatment. First-line treatment strategies can cure only a minority of patients and relapsed-refractory disease still represents the major cause of failure. Frontline autologous transplantation may have an impact in the consolidation of response; however, its role is still questioned as far as complete responses obtained after induction chemotherapy are concerned. Newer drugs are now being evaluated in clinical trials, but effective salvage strategies for those who experience treatment failures are lacking. Here we review and discuss the most controversial aspects of diagnosis and treatment of peripheral T-cell lymphomas.