Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B

Herein, two new series of N-substituted indole-based analogues were rationally designed, synthesized via microwave heating technology, and evaluated as noteworthy MAO-B potential inhibitors. Compared to the reported indazole-based hits VI and VII, compounds 4b and 4e exhibited higher inhibitory acti...

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Detalles Bibliográficos
Autores principales: Elkamhawy, Ahmed, Paik, Sora, Kim, Hyeon Jeong, Park, Jong-Hyun, Londhe, Ashwini M., Lee, Kyeong, Pae, Ae Nim, Park, Ki Duk, Roh, Eun Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470070/
https://www.ncbi.nlm.nih.gov/pubmed/32752896
http://dx.doi.org/10.1080/14756366.2020.1800666

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