A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods

Icaritin (ICT) and hydrous icaritin (HICT) are two similar flavonoids compounds isolated from Epimedium Genus. This is the first comparative study on their in vitro and in vivo antitumor effects. Nanorods (NRs) were prepared for ICT and HICT by anti-solvent precipitation method using D-alpha tocophe...

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Autores principales: Li, Haowen, Li, Yijing, Ao, Hui, Fu, Jingxin, Guo, Yifei, Han, Meihua, Yan, Xueying, Chen, Xi, Wang, Xiangtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
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Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470086/
https://www.ncbi.nlm.nih.gov/pubmed/32762483
http://dx.doi.org/10.1080/10717544.2020.1801892
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author Li, Haowen
Li, Yijing
Ao, Hui
Fu, Jingxin
Guo, Yifei
Han, Meihua
Yan, Xueying
Chen, Xi
Wang, Xiangtao
author_facet Li, Haowen
Li, Yijing
Ao, Hui
Fu, Jingxin
Guo, Yifei
Han, Meihua
Yan, Xueying
Chen, Xi
Wang, Xiangtao
author_sort Li, Haowen
collection PubMed
description Icaritin (ICT) and hydrous icaritin (HICT) are two similar flavonoids compounds isolated from Epimedium Genus. This is the first comparative study on their in vitro and in vivo antitumor effects. Nanorods (NRs) were prepared for ICT and HICT by anti-solvent precipitation method using D-alpha tocopherol acid polyethylene glycol succinate (TPGS) as a stabilizer. The prepared ICT-NRs and HICT-NRs had similar diameter (155.5 nm and 201.7 nm), high drug loading content (43.30 ± 0.22% and 41.08 ± 0.19%), excellent stability and a similar sustaining drug release manner. Nanorods improved the in vitro toxicity against 4 different cancer cells in contrast to free ICT or free HICT; however, no significant difference was observed in this regard between ICT-NRs and HICT NRs. In the in vivo study on the anticancer efficacy on MCF-7 and PLC/PRE/5 tumor-bearing mice model, HICR-NRs displayed certain advantage over ICT NRs with higher tumor inhibition rate.
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spelling pubmed-74700862020-09-15 A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods Li, Haowen Li, Yijing Ao, Hui Fu, Jingxin Guo, Yifei Han, Meihua Yan, Xueying Chen, Xi Wang, Xiangtao Drug Deliv Research Article Icaritin (ICT) and hydrous icaritin (HICT) are two similar flavonoids compounds isolated from Epimedium Genus. This is the first comparative study on their in vitro and in vivo antitumor effects. Nanorods (NRs) were prepared for ICT and HICT by anti-solvent precipitation method using D-alpha tocopherol acid polyethylene glycol succinate (TPGS) as a stabilizer. The prepared ICT-NRs and HICT-NRs had similar diameter (155.5 nm and 201.7 nm), high drug loading content (43.30 ± 0.22% and 41.08 ± 0.19%), excellent stability and a similar sustaining drug release manner. Nanorods improved the in vitro toxicity against 4 different cancer cells in contrast to free ICT or free HICT; however, no significant difference was observed in this regard between ICT-NRs and HICT NRs. In the in vivo study on the anticancer efficacy on MCF-7 and PLC/PRE/5 tumor-bearing mice model, HICR-NRs displayed certain advantage over ICT NRs with higher tumor inhibition rate. Taylor & Francis 2020-08-07 /pmc/articles/PMC7470086/ /pubmed/32762483 http://dx.doi.org/10.1080/10717544.2020.1801892 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Haowen
Li, Yijing
Ao, Hui
Fu, Jingxin
Guo, Yifei
Han, Meihua
Yan, Xueying
Chen, Xi
Wang, Xiangtao
A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods
title A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods
title_full A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods
title_fullStr A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods
title_full_unstemmed A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods
title_short A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods
title_sort comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470086/
https://www.ncbi.nlm.nih.gov/pubmed/32762483
http://dx.doi.org/10.1080/10717544.2020.1801892
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