Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1)

Poly(ADP-ribose) polymerase-1 (PARP-1), a critical DNA repair enzyme in the base excision repair pathway, has been pursued as an attractive cancer therapeutic target. Intervention with PARP-1 has been proved to be more sensitive to cancer cells carrying BRCA1/2 mutations. Several PARP-1 inhibitors h...

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Detalles Bibliográficos
Autores principales: Zhang, Zhimin, Chang, Xinyue, Zhang, Chixiao, Zeng, Shenxin, Liang, Meihao, Ma, Zhen, Wang, Zunyuan, Huang, Wenhai, Shen, Zhengrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470090/
https://www.ncbi.nlm.nih.gov/pubmed/32779949
http://dx.doi.org/10.1080/14756366.2020.1804382

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