Immune Reconstitution Disorders: Spotlight on Interferons

Three decades of research in hematopoietic stem cell transplantation and HIV/AIDS fields have shaped a picture of immune restoration disorders. This manuscript overviews the molecular biology of interferon networks, the molecular pathogenesis of immune reconstitution inflammatory syndrome, and post-...

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Detalles Bibliográficos
Autores principales: Mohei, Hesham, Kellampalli, Usha, Vlasova-St. Louis, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470101/
https://www.ncbi.nlm.nih.gov/pubmed/32905461
http://dx.doi.org/10.31531/2581-4745.1000119
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author Mohei, Hesham
Kellampalli, Usha
Vlasova-St. Louis, Irina
author_facet Mohei, Hesham
Kellampalli, Usha
Vlasova-St. Louis, Irina
author_sort Mohei, Hesham
collection PubMed
description Three decades of research in hematopoietic stem cell transplantation and HIV/AIDS fields have shaped a picture of immune restoration disorders. This manuscript overviews the molecular biology of interferon networks, the molecular pathogenesis of immune reconstitution inflammatory syndrome, and post-hematopoietic stem cell transplantation immune restoration disorders (IRD). It also summarizes the effects of thymic involution on T cell diversity, and the results of the assessment of diagnostic biomarkers of IRD, and tested targeted immunomodulatory treatments
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spelling pubmed-74701012020-09-03 Immune Reconstitution Disorders: Spotlight on Interferons Mohei, Hesham Kellampalli, Usha Vlasova-St. Louis, Irina Int J Biomed Investig Article Three decades of research in hematopoietic stem cell transplantation and HIV/AIDS fields have shaped a picture of immune restoration disorders. This manuscript overviews the molecular biology of interferon networks, the molecular pathogenesis of immune reconstitution inflammatory syndrome, and post-hematopoietic stem cell transplantation immune restoration disorders (IRD). It also summarizes the effects of thymic involution on T cell diversity, and the results of the assessment of diagnostic biomarkers of IRD, and tested targeted immunomodulatory treatments 2019 /pmc/articles/PMC7470101/ /pubmed/32905461 http://dx.doi.org/10.31531/2581-4745.1000119 Text en This article is distributed under the terms of the Creative Commons Attribution 4.0 International License [http://creativecommons.org/licenses/by/4.0/], which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author[s] and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Mohei, Hesham
Kellampalli, Usha
Vlasova-St. Louis, Irina
Immune Reconstitution Disorders: Spotlight on Interferons
title Immune Reconstitution Disorders: Spotlight on Interferons
title_full Immune Reconstitution Disorders: Spotlight on Interferons
title_fullStr Immune Reconstitution Disorders: Spotlight on Interferons
title_full_unstemmed Immune Reconstitution Disorders: Spotlight on Interferons
title_short Immune Reconstitution Disorders: Spotlight on Interferons
title_sort immune reconstitution disorders: spotlight on interferons
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470101/
https://www.ncbi.nlm.nih.gov/pubmed/32905461
http://dx.doi.org/10.31531/2581-4745.1000119
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