Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors

Aza-peptide aldehydes and ketones are a new class of reversible protease inhibitors that are specific for the proteasome and clan CD cysteine proteases. We designed and synthesised aza-Leu derivatives that were specific for the chymotrypsin-like active site of the proteasome, aza-Asp derivatives tha...

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Detalles Bibliográficos
Autores principales: Corrigan, Thomas S., Lotti Diaz, Leilani M., Border, Sarah E., Ratigan, Steven C., Kasper, Kayla Q., Sojka, Daniel, Fajtova, Pavla, Caffrey, Conor R., Salvesen, Guy S., McElroy, Craig A., Hadad, Christopher M., Doğan Ekici, Özlem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470110/
https://www.ncbi.nlm.nih.gov/pubmed/32633155
http://dx.doi.org/10.1080/14756366.2020.1781107

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