Potential anti-neuroinflammatory NF-кB inhibitors based on 3,4-dihydronaphthalen-1(2H)-one derivatives

Nuclear factor kappa B (NF-кB) inhibition represents a new therapeutic strategy for the treatment of neuroinflammatory diseases. In this study, a series of 3,4-dihydronaphthalen-1(2H)-one (DHN; 6a-n, 7a-c) derivatives were synthesised and characterised by NMR and HRMS. We assessed the toxicity and a...

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Detalles Bibliográficos
Autores principales: Sun, Yue, Zhou, Yan-Qiu, Liu, Yin-Kai, Zhang, Hong-Qin, Hou, Gui-Ge, Meng, Qing-Guo, Hou, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470122/
https://www.ncbi.nlm.nih.gov/pubmed/32781863
http://dx.doi.org/10.1080/14756366.2020.1804899

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