Genetic Engineering to Induce Fetal-Like Hematopoietic Stem Cells

Bone marrow transplantation (BMT) or hematopoietic stem cell transplantation (HSCT) is an archetype of cellular therapy. However, to date BMT still suffers from several complications. Recent technological advances have encouraged us to think about an alternative to traditional BMT. Specifically, we...

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Detalles Bibliográficos
Autores principales: Ulum, Bariş, Muljo, Stefan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470128/
https://www.ncbi.nlm.nih.gov/pubmed/32905347
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author Ulum, Bariş
Muljo, Stefan A.
author_facet Ulum, Bariş
Muljo, Stefan A.
author_sort Ulum, Bariş
collection PubMed
description Bone marrow transplantation (BMT) or hematopoietic stem cell transplantation (HSCT) is an archetype of cellular therapy. However, to date BMT still suffers from several complications. Recent technological advances have encouraged us to think about an alternative to traditional BMT. Specifically, we propose in utero HSCT (IUHSCT). For this purpose, we suggest that induced fetal-like hematopoietic stem cells (ifHSCs) might be suitable for IUHSCT, and should be seriously evaluated.
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spelling pubmed-74701282020-09-03 Genetic Engineering to Induce Fetal-Like Hematopoietic Stem Cells Ulum, Bariş Muljo, Stefan A. Gene Technol Article Bone marrow transplantation (BMT) or hematopoietic stem cell transplantation (HSCT) is an archetype of cellular therapy. However, to date BMT still suffers from several complications. Recent technological advances have encouraged us to think about an alternative to traditional BMT. Specifically, we propose in utero HSCT (IUHSCT). For this purpose, we suggest that induced fetal-like hematopoietic stem cells (ifHSCs) might be suitable for IUHSCT, and should be seriously evaluated. 2020 /pmc/articles/PMC7470128/ /pubmed/32905347 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Article
Ulum, Bariş
Muljo, Stefan A.
Genetic Engineering to Induce Fetal-Like Hematopoietic Stem Cells
title Genetic Engineering to Induce Fetal-Like Hematopoietic Stem Cells
title_full Genetic Engineering to Induce Fetal-Like Hematopoietic Stem Cells
title_fullStr Genetic Engineering to Induce Fetal-Like Hematopoietic Stem Cells
title_full_unstemmed Genetic Engineering to Induce Fetal-Like Hematopoietic Stem Cells
title_short Genetic Engineering to Induce Fetal-Like Hematopoietic Stem Cells
title_sort genetic engineering to induce fetal-like hematopoietic stem cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470128/
https://www.ncbi.nlm.nih.gov/pubmed/32905347
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