L-arginine effects on cerebrovascular reactivity, perfusion and neurovascular coupling in MELAS (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) syndrome

OBJECTIVE: We previously showed that MELAS patients have decreased cerebrovascular reactivity (CVR) (p≤ 0.002) and increased cerebral blood flow (CBF) (p<0.0026); changes correlated with disease severity and % mutant mtDNA (inversely for CVR; directly for CBF). We ran a prospective pilot in 3 MEL...

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Detalles Bibliográficos
Autores principales: Rodan, Lance H., Poublanc, Julien, Fisher, Joseph A., Sobczyk, Olivia, Mikulis, David J., Tein, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470264/
https://www.ncbi.nlm.nih.gov/pubmed/32881886
http://dx.doi.org/10.1371/journal.pone.0238224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470264/
https://www.ncbi.nlm.nih.gov/pubmed/32881886
http://dx.doi.org/10.1371/journal.pone.0238224

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