Cargando…

Expression changes of cytotoxicity and apoptosis genes in HTLV-1-associated myelopathy/tropical spastic paraparesis patients from the perspective of system virology

Although human T-cell lymphotropic virus type-1 (HTLV-1) was the first retrovirus among human pathogens to be identified, insufficient information on the pathogenesis of HTLV-1 infection means that no precise mechanism has yet been provided for HTLV-1-associated myelopathy/tropical spastic parapares...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghazvini, Kiarash, Youssefi, Masoud, Keikha, Masoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470310/
https://www.ncbi.nlm.nih.gov/pubmed/32974568
http://dx.doi.org/10.1099/acmi.0.000088
_version_ 1783578559804080128
author Ghazvini, Kiarash
Youssefi, Masoud
Keikha, Masoud
author_facet Ghazvini, Kiarash
Youssefi, Masoud
Keikha, Masoud
author_sort Ghazvini, Kiarash
collection PubMed
description Although human T-cell lymphotropic virus type-1 (HTLV-1) was the first retrovirus among human pathogens to be identified, insufficient information on the pathogenesis of HTLV-1 infection means that no precise mechanism has yet been provided for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Based on previous studies, it was found that apoptosis and inflammation stimulation were among the most important mechanisms underlying HAM/TSP. The present study provides an in-silico analysis of the microarray data related to HAM/TSP patients. Expression changes of the genes responsible for cytotoxicity and apoptosis processes of HAM/TSP patients and asymptomatic carriers were investigated. Expression of the genes involved in cytotoxicity and apoptosis in HAM/TSP patients was decreased; hence, a model was proposed indicating that the spread of immune responses in HAM/TSP may be due to expression of HTLV-1 virulence factors and the resistance of HTLV-1-infected cells to apoptosis.
format Online
Article
Text
id pubmed-7470310
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Microbiology Society
record_format MEDLINE/PubMed
spelling pubmed-74703102020-09-23 Expression changes of cytotoxicity and apoptosis genes in HTLV-1-associated myelopathy/tropical spastic paraparesis patients from the perspective of system virology Ghazvini, Kiarash Youssefi, Masoud Keikha, Masoud Access Microbiol Research Article Although human T-cell lymphotropic virus type-1 (HTLV-1) was the first retrovirus among human pathogens to be identified, insufficient information on the pathogenesis of HTLV-1 infection means that no precise mechanism has yet been provided for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Based on previous studies, it was found that apoptosis and inflammation stimulation were among the most important mechanisms underlying HAM/TSP. The present study provides an in-silico analysis of the microarray data related to HAM/TSP patients. Expression changes of the genes responsible for cytotoxicity and apoptosis processes of HAM/TSP patients and asymptomatic carriers were investigated. Expression of the genes involved in cytotoxicity and apoptosis in HAM/TSP patients was decreased; hence, a model was proposed indicating that the spread of immune responses in HAM/TSP may be due to expression of HTLV-1 virulence factors and the resistance of HTLV-1-infected cells to apoptosis. Microbiology Society 2020-01-14 /pmc/articles/PMC7470310/ /pubmed/32974568 http://dx.doi.org/10.1099/acmi.0.000088 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Ghazvini, Kiarash
Youssefi, Masoud
Keikha, Masoud
Expression changes of cytotoxicity and apoptosis genes in HTLV-1-associated myelopathy/tropical spastic paraparesis patients from the perspective of system virology
title Expression changes of cytotoxicity and apoptosis genes in HTLV-1-associated myelopathy/tropical spastic paraparesis patients from the perspective of system virology
title_full Expression changes of cytotoxicity and apoptosis genes in HTLV-1-associated myelopathy/tropical spastic paraparesis patients from the perspective of system virology
title_fullStr Expression changes of cytotoxicity and apoptosis genes in HTLV-1-associated myelopathy/tropical spastic paraparesis patients from the perspective of system virology
title_full_unstemmed Expression changes of cytotoxicity and apoptosis genes in HTLV-1-associated myelopathy/tropical spastic paraparesis patients from the perspective of system virology
title_short Expression changes of cytotoxicity and apoptosis genes in HTLV-1-associated myelopathy/tropical spastic paraparesis patients from the perspective of system virology
title_sort expression changes of cytotoxicity and apoptosis genes in htlv-1-associated myelopathy/tropical spastic paraparesis patients from the perspective of system virology
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470310/
https://www.ncbi.nlm.nih.gov/pubmed/32974568
http://dx.doi.org/10.1099/acmi.0.000088
work_keys_str_mv AT ghazvinikiarash expressionchangesofcytotoxicityandapoptosisgenesinhtlv1associatedmyelopathytropicalspasticparaparesispatientsfromtheperspectiveofsystemvirology
AT youssefimasoud expressionchangesofcytotoxicityandapoptosisgenesinhtlv1associatedmyelopathytropicalspasticparaparesispatientsfromtheperspectiveofsystemvirology
AT keikhamasoud expressionchangesofcytotoxicityandapoptosisgenesinhtlv1associatedmyelopathytropicalspasticparaparesispatientsfromtheperspectiveofsystemvirology