Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis

There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment times. Using a fluorescent rifampicin conjugate, we demonstrated that synergy between cell wall inhibitors and rifampicin was associated with inc...

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Detalles Bibliográficos
Autores principales: McNeil, Matthew B., Chettiar, Somsundaram, Awasthi, Divya, Parish, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470358/
https://www.ncbi.nlm.nih.gov/pubmed/32974492
http://dx.doi.org/10.1099/acmi.0.000006
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author McNeil, Matthew B.
Chettiar, Somsundaram
Awasthi, Divya
Parish, Tanya
author_facet McNeil, Matthew B.
Chettiar, Somsundaram
Awasthi, Divya
Parish, Tanya
author_sort McNeil, Matthew B.
collection PubMed
description There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment times. Using a fluorescent rifampicin conjugate, we demonstrated that synergy between cell wall inhibitors and rifampicin was associated with increased accumulation of rifampicin. Increased accumulation was also associated with increased cellular permeability.
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spelling pubmed-74703582020-09-23 Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis McNeil, Matthew B. Chettiar, Somsundaram Awasthi, Divya Parish, Tanya Access Microbiol Short Communication There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment times. Using a fluorescent rifampicin conjugate, we demonstrated that synergy between cell wall inhibitors and rifampicin was associated with increased accumulation of rifampicin. Increased accumulation was also associated with increased cellular permeability. Microbiology Society 2019-03-20 /pmc/articles/PMC7470358/ /pubmed/32974492 http://dx.doi.org/10.1099/acmi.0.000006 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License.
spellingShingle Short Communication
McNeil, Matthew B.
Chettiar, Somsundaram
Awasthi, Divya
Parish, Tanya
Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis
title Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis
title_full Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis
title_fullStr Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis
title_full_unstemmed Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis
title_short Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis
title_sort cell wall inhibitors increase the accumulation of rifampicin in mycobacterium tuberculosis
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470358/
https://www.ncbi.nlm.nih.gov/pubmed/32974492
http://dx.doi.org/10.1099/acmi.0.000006
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AT awasthidivya cellwallinhibitorsincreasetheaccumulationofrifampicininmycobacteriumtuberculosis
AT parishtanya cellwallinhibitorsincreasetheaccumulationofrifampicininmycobacteriumtuberculosis

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