High-resolution analysis of Merkel Cell Polyomavirus in Merkel Cell Carcinoma reveals distinct integration patterns and suggests NHEJ and MMBIR as underlying mechanisms

Merkel Cell Polyomavirus (MCPyV) is the etiological agent of the majority of Merkel Cell Carcinomas (MCC). MCPyV positive MCCs harbor integrated, defective viral genomes that constitutively express viral oncogenes. Which molecular mechanisms promote viral integration, if distinct integration pattern...

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Detalles Bibliográficos
Autores principales: Czech-Sioli, Manja, Günther, Thomas, Therre, Marlin, Spohn, Michael, Indenbirken, Daniela, Theiss, Juliane, Riethdorf, Sabine, Qi, Minyue, Alawi, Malik, Wülbeck, Corinna, Fernandez-Cuesta, Irene, Esmek, Franziska, Becker, Jürgen C., Grundhoff, Adam, Fischer, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470373/
https://www.ncbi.nlm.nih.gov/pubmed/32833988
http://dx.doi.org/10.1371/journal.ppat.1008562

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