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Progressive active mobilization with dose control and training load in critically ill patients (PROMOB): Protocol for a randomized controlled trial

The dose of progressive active mobilization is still uncertain. The purpose of this study is to identify if the addition of a protocol of progressive active mobilization with dose and training load control to usual care is effective in reducing the length of stay in intensive care unit (ICU) and the...

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Autores principales: de Queiroz, Rodrigo Santos, Saquetto, Micheli Bernardone, Martinez, Bruno Prata, Cazeta, Bianca Bigogno Reis, Hodgson, Carol, Gomes-Neto, Mansueto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470388/
https://www.ncbi.nlm.nih.gov/pubmed/32881921
http://dx.doi.org/10.1371/journal.pone.0238352
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author de Queiroz, Rodrigo Santos
Saquetto, Micheli Bernardone
Martinez, Bruno Prata
Cazeta, Bianca Bigogno Reis
Hodgson, Carol
Gomes-Neto, Mansueto
author_facet de Queiroz, Rodrigo Santos
Saquetto, Micheli Bernardone
Martinez, Bruno Prata
Cazeta, Bianca Bigogno Reis
Hodgson, Carol
Gomes-Neto, Mansueto
author_sort de Queiroz, Rodrigo Santos
collection PubMed
description The dose of progressive active mobilization is still uncertain. The purpose of this study is to identify if the addition of a protocol of progressive active mobilization with dose and training load control to usual care is effective in reducing the length of stay in intensive care unit (ICU) and the improvement of the functioning, incidence of ICU-acquired weakness (ICUAW), mechanical ventilation duration and mortality rate in patients hospitalized in ICU. It is Double-blind randomised clinical trial. The setting for this trial will be medical and surgical ICU of a university hospital. The study participants will be 118 patients aged> 18 years admitted to ICU for less than 72 hours. Participants will be randomized to either an experimental or control group. The experimental group will undertake addition of a protocol of progressive active mobilization with dose and training load control to usual care, while the control group will undertake only usual care. The primary outcome will be length of ICU stay. The secondary outcomes will be Cross-sectional area and muscle thickness of the rectus femoris and biceps brachii, Change in muscle strength from the baseline, Functional Status, incidence of ICUAW, Days with mechanical ventilation and Mortality. All statistical analyses will be conducted following intention-to-treat principles. It has a detailed description of the dose of exercise, was designed with the strictest methodological criteria. These characteristics allow to investigate with greater certainty the results progressive active mobilization in critical patients, allowing replication and future combinations in meta-analyzes.
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spelling pubmed-74703882020-09-11 Progressive active mobilization with dose control and training load in critically ill patients (PROMOB): Protocol for a randomized controlled trial de Queiroz, Rodrigo Santos Saquetto, Micheli Bernardone Martinez, Bruno Prata Cazeta, Bianca Bigogno Reis Hodgson, Carol Gomes-Neto, Mansueto PLoS One Registered Report Protocol The dose of progressive active mobilization is still uncertain. The purpose of this study is to identify if the addition of a protocol of progressive active mobilization with dose and training load control to usual care is effective in reducing the length of stay in intensive care unit (ICU) and the improvement of the functioning, incidence of ICU-acquired weakness (ICUAW), mechanical ventilation duration and mortality rate in patients hospitalized in ICU. It is Double-blind randomised clinical trial. The setting for this trial will be medical and surgical ICU of a university hospital. The study participants will be 118 patients aged> 18 years admitted to ICU for less than 72 hours. Participants will be randomized to either an experimental or control group. The experimental group will undertake addition of a protocol of progressive active mobilization with dose and training load control to usual care, while the control group will undertake only usual care. The primary outcome will be length of ICU stay. The secondary outcomes will be Cross-sectional area and muscle thickness of the rectus femoris and biceps brachii, Change in muscle strength from the baseline, Functional Status, incidence of ICUAW, Days with mechanical ventilation and Mortality. All statistical analyses will be conducted following intention-to-treat principles. It has a detailed description of the dose of exercise, was designed with the strictest methodological criteria. These characteristics allow to investigate with greater certainty the results progressive active mobilization in critical patients, allowing replication and future combinations in meta-analyzes. Public Library of Science 2020-09-03 /pmc/articles/PMC7470388/ /pubmed/32881921 http://dx.doi.org/10.1371/journal.pone.0238352 Text en © 2020 Queiroz et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Registered Report Protocol
de Queiroz, Rodrigo Santos
Saquetto, Micheli Bernardone
Martinez, Bruno Prata
Cazeta, Bianca Bigogno Reis
Hodgson, Carol
Gomes-Neto, Mansueto
Progressive active mobilization with dose control and training load in critically ill patients (PROMOB): Protocol for a randomized controlled trial
title Progressive active mobilization with dose control and training load in critically ill patients (PROMOB): Protocol for a randomized controlled trial
title_full Progressive active mobilization with dose control and training load in critically ill patients (PROMOB): Protocol for a randomized controlled trial
title_fullStr Progressive active mobilization with dose control and training load in critically ill patients (PROMOB): Protocol for a randomized controlled trial
title_full_unstemmed Progressive active mobilization with dose control and training load in critically ill patients (PROMOB): Protocol for a randomized controlled trial
title_short Progressive active mobilization with dose control and training load in critically ill patients (PROMOB): Protocol for a randomized controlled trial
title_sort progressive active mobilization with dose control and training load in critically ill patients (promob): protocol for a randomized controlled trial
topic Registered Report Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470388/
https://www.ncbi.nlm.nih.gov/pubmed/32881921
http://dx.doi.org/10.1371/journal.pone.0238352
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