Cargando…
Efficacy of Mass Azithromycin Distribution for Reducing Childhood Mortality Across Geographic Regions
Mass azithromycin distribution has been shown to reduce all-cause mortality in preschool children in sub-Saharan Africa. However, substantial heterogeneity in the apparent effect has been noted across geographic settings, suggesting a greater relative benefit in higher mortality settings. Here, we e...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society of Tropical Medicine and Hygiene
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470520/ https://www.ncbi.nlm.nih.gov/pubmed/30734695 http://dx.doi.org/10.4269/ajtmh.18-1003 |
_version_ | 1783578602506289152 |
---|---|
author | Porco, Travis C. Oldenburg, Catherine E. Arzika, Ahmed M. Kalua, Khumbo Mrango, Zakayo Cook, Catherine Lebas, Elodie Bailey, Robin L. West, Sheila K. Oron, Assaf P. Keenan, Jeremy D. Lietman, Thomas M. |
author_facet | Porco, Travis C. Oldenburg, Catherine E. Arzika, Ahmed M. Kalua, Khumbo Mrango, Zakayo Cook, Catherine Lebas, Elodie Bailey, Robin L. West, Sheila K. Oron, Assaf P. Keenan, Jeremy D. Lietman, Thomas M. |
author_sort | Porco, Travis C. |
collection | PubMed |
description | Mass azithromycin distribution has been shown to reduce all-cause mortality in preschool children in sub-Saharan Africa. However, substantial heterogeneity in the apparent effect has been noted across geographic settings, suggesting a greater relative benefit in higher mortality settings. Here, we evaluated the relationship between the underlying mortality rate and the efficacy of azithromycin for the prevention of child mortality using data from multiple sites in Ethiopia, Malawi, Niger, and Tanzania. Between regions, we find no strong evidence of effect modification of the efficacy of azithromycin distribution for the prevention of child mortality by the underlying mortality rate (P = 0.12), although a modest effect is consistent with our findings. Higher mortality settings could be prioritized, however, because of the larger number of deaths which could be averted with azithromycin distribution. |
format | Online Article Text |
id | pubmed-7470520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The American Society of Tropical Medicine and Hygiene |
record_format | MEDLINE/PubMed |
spelling | pubmed-74705202020-09-04 Efficacy of Mass Azithromycin Distribution for Reducing Childhood Mortality Across Geographic Regions Porco, Travis C. Oldenburg, Catherine E. Arzika, Ahmed M. Kalua, Khumbo Mrango, Zakayo Cook, Catherine Lebas, Elodie Bailey, Robin L. West, Sheila K. Oron, Assaf P. Keenan, Jeremy D. Lietman, Thomas M. Am J Trop Med Hyg Articles Mass azithromycin distribution has been shown to reduce all-cause mortality in preschool children in sub-Saharan Africa. However, substantial heterogeneity in the apparent effect has been noted across geographic settings, suggesting a greater relative benefit in higher mortality settings. Here, we evaluated the relationship between the underlying mortality rate and the efficacy of azithromycin for the prevention of child mortality using data from multiple sites in Ethiopia, Malawi, Niger, and Tanzania. Between regions, we find no strong evidence of effect modification of the efficacy of azithromycin distribution for the prevention of child mortality by the underlying mortality rate (P = 0.12), although a modest effect is consistent with our findings. Higher mortality settings could be prioritized, however, because of the larger number of deaths which could be averted with azithromycin distribution. The American Society of Tropical Medicine and Hygiene 2020-09 2019-02-07 /pmc/articles/PMC7470520/ /pubmed/30734695 http://dx.doi.org/10.4269/ajtmh.18-1003 Text en © The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Articles Porco, Travis C. Oldenburg, Catherine E. Arzika, Ahmed M. Kalua, Khumbo Mrango, Zakayo Cook, Catherine Lebas, Elodie Bailey, Robin L. West, Sheila K. Oron, Assaf P. Keenan, Jeremy D. Lietman, Thomas M. Efficacy of Mass Azithromycin Distribution for Reducing Childhood Mortality Across Geographic Regions |
title | Efficacy of Mass Azithromycin Distribution for Reducing Childhood Mortality Across Geographic Regions |
title_full | Efficacy of Mass Azithromycin Distribution for Reducing Childhood Mortality Across Geographic Regions |
title_fullStr | Efficacy of Mass Azithromycin Distribution for Reducing Childhood Mortality Across Geographic Regions |
title_full_unstemmed | Efficacy of Mass Azithromycin Distribution for Reducing Childhood Mortality Across Geographic Regions |
title_short | Efficacy of Mass Azithromycin Distribution for Reducing Childhood Mortality Across Geographic Regions |
title_sort | efficacy of mass azithromycin distribution for reducing childhood mortality across geographic regions |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470520/ https://www.ncbi.nlm.nih.gov/pubmed/30734695 http://dx.doi.org/10.4269/ajtmh.18-1003 |
work_keys_str_mv | AT porcotravisc efficacyofmassazithromycindistributionforreducingchildhoodmortalityacrossgeographicregions AT oldenburgcatherinee efficacyofmassazithromycindistributionforreducingchildhoodmortalityacrossgeographicregions AT arzikaahmedm efficacyofmassazithromycindistributionforreducingchildhoodmortalityacrossgeographicregions AT kaluakhumbo efficacyofmassazithromycindistributionforreducingchildhoodmortalityacrossgeographicregions AT mrangozakayo efficacyofmassazithromycindistributionforreducingchildhoodmortalityacrossgeographicregions AT cookcatherine efficacyofmassazithromycindistributionforreducingchildhoodmortalityacrossgeographicregions AT lebaselodie efficacyofmassazithromycindistributionforreducingchildhoodmortalityacrossgeographicregions AT baileyrobinl efficacyofmassazithromycindistributionforreducingchildhoodmortalityacrossgeographicregions AT westsheilak efficacyofmassazithromycindistributionforreducingchildhoodmortalityacrossgeographicregions AT oronassafp efficacyofmassazithromycindistributionforreducingchildhoodmortalityacrossgeographicregions AT keenanjeremyd efficacyofmassazithromycindistributionforreducingchildhoodmortalityacrossgeographicregions AT lietmanthomasm efficacyofmassazithromycindistributionforreducingchildhoodmortalityacrossgeographicregions AT efficacyofmassazithromycindistributionforreducingchildhoodmortalityacrossgeographicregions |