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Elimination of Simulium neavei–Transmitted Onchocerciasis in Wambabya–Rwamarongo Focus of Western Uganda

Wambabya–Rwamarongo onchocerciasis focus is one of the eight foci Uganda verified using the WHO verification guidelines. The approach for elimination was twice yearly treatment with ivermectin for every round, treating at least 90% of all the eligible population. This was in combination with vector...

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Autores principales: Katabarwa, Moses N., Habomugisha, Peace, Khainza, Annet, Oguttu, David, Byamukama, Edson, Katamanywa, James, Isingooma, Thomson, Bwenume, Fredrick, Nahabwe, Christine, Ngabirano, Monica, Akampurira, Paul, Bernard, Lauri, Unnasch, Thomas R., Richards, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470550/
https://www.ncbi.nlm.nih.gov/pubmed/32588807
http://dx.doi.org/10.4269/ajtmh.20-0195
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author Katabarwa, Moses N.
Habomugisha, Peace
Khainza, Annet
Oguttu, David
Byamukama, Edson
Katamanywa, James
Isingooma, Thomson
Bwenume, Fredrick
Nahabwe, Christine
Ngabirano, Monica
Akampurira, Paul
Bernard, Lauri
Unnasch, Thomas R.
Richards, Frank
author_facet Katabarwa, Moses N.
Habomugisha, Peace
Khainza, Annet
Oguttu, David
Byamukama, Edson
Katamanywa, James
Isingooma, Thomson
Bwenume, Fredrick
Nahabwe, Christine
Ngabirano, Monica
Akampurira, Paul
Bernard, Lauri
Unnasch, Thomas R.
Richards, Frank
author_sort Katabarwa, Moses N.
collection PubMed
description Wambabya–Rwamarongo onchocerciasis focus is one of the eight foci Uganda verified using the WHO verification guidelines. The approach for elimination was twice yearly treatment with ivermectin for every round, treating at least 90% of all the eligible population. This was in combination with vector elimination using Abate(®) (BASF SE, Limburgerhof, Germany) since elimination nationwide policy was launched. From 2008 to 2013, the program distributed ivermectin with a mean treatment coverage of the ultimate treatment goal (UTG) or eligible population of 91.2%, with a range of 85–96%. In 2009, vector elimination based on ground larviciding had a dramatic impact on the Simulium vectors, as the last fly was observed in October 2009. No more Simulium vectors were observed during a period of at least 7 years, including the 3-year posttreatment surveillance (PTS) until the focus was reclassified as eliminated in August 2017. During the PTS period, none of the 10,578 trapped crabs were found infested with the aquatic stages of the vector. The last infested crab was observed in March 2010, and for at least 7 years, no infested crabs were observed. Serological surveys showed that of 2,978 young children examined in 2013, only one was OV16 positive (0.0%; 95% CI: 0–0.21). In 2017, after the PTS period, all 3,079 young children examined were negative for OV16 (95% CI: 0–0.16). Therefore, entomological and serological results provided evidence that resulted in the reclassification of Wambabya–Rwamarongo focus from “transmission interrupted” to “transmission eliminated” with no possibility of recrudescence.
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spelling pubmed-74705502020-09-04 Elimination of Simulium neavei–Transmitted Onchocerciasis in Wambabya–Rwamarongo Focus of Western Uganda Katabarwa, Moses N. Habomugisha, Peace Khainza, Annet Oguttu, David Byamukama, Edson Katamanywa, James Isingooma, Thomson Bwenume, Fredrick Nahabwe, Christine Ngabirano, Monica Akampurira, Paul Bernard, Lauri Unnasch, Thomas R. Richards, Frank Am J Trop Med Hyg Articles Wambabya–Rwamarongo onchocerciasis focus is one of the eight foci Uganda verified using the WHO verification guidelines. The approach for elimination was twice yearly treatment with ivermectin for every round, treating at least 90% of all the eligible population. This was in combination with vector elimination using Abate(®) (BASF SE, Limburgerhof, Germany) since elimination nationwide policy was launched. From 2008 to 2013, the program distributed ivermectin with a mean treatment coverage of the ultimate treatment goal (UTG) or eligible population of 91.2%, with a range of 85–96%. In 2009, vector elimination based on ground larviciding had a dramatic impact on the Simulium vectors, as the last fly was observed in October 2009. No more Simulium vectors were observed during a period of at least 7 years, including the 3-year posttreatment surveillance (PTS) until the focus was reclassified as eliminated in August 2017. During the PTS period, none of the 10,578 trapped crabs were found infested with the aquatic stages of the vector. The last infested crab was observed in March 2010, and for at least 7 years, no infested crabs were observed. Serological surveys showed that of 2,978 young children examined in 2013, only one was OV16 positive (0.0%; 95% CI: 0–0.21). In 2017, after the PTS period, all 3,079 young children examined were negative for OV16 (95% CI: 0–0.16). Therefore, entomological and serological results provided evidence that resulted in the reclassification of Wambabya–Rwamarongo focus from “transmission interrupted” to “transmission eliminated” with no possibility of recrudescence. The American Society of Tropical Medicine and Hygiene 2020-09 2020-06-22 /pmc/articles/PMC7470550/ /pubmed/32588807 http://dx.doi.org/10.4269/ajtmh.20-0195 Text en © The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Katabarwa, Moses N.
Habomugisha, Peace
Khainza, Annet
Oguttu, David
Byamukama, Edson
Katamanywa, James
Isingooma, Thomson
Bwenume, Fredrick
Nahabwe, Christine
Ngabirano, Monica
Akampurira, Paul
Bernard, Lauri
Unnasch, Thomas R.
Richards, Frank
Elimination of Simulium neavei–Transmitted Onchocerciasis in Wambabya–Rwamarongo Focus of Western Uganda
title Elimination of Simulium neavei–Transmitted Onchocerciasis in Wambabya–Rwamarongo Focus of Western Uganda
title_full Elimination of Simulium neavei–Transmitted Onchocerciasis in Wambabya–Rwamarongo Focus of Western Uganda
title_fullStr Elimination of Simulium neavei–Transmitted Onchocerciasis in Wambabya–Rwamarongo Focus of Western Uganda
title_full_unstemmed Elimination of Simulium neavei–Transmitted Onchocerciasis in Wambabya–Rwamarongo Focus of Western Uganda
title_short Elimination of Simulium neavei–Transmitted Onchocerciasis in Wambabya–Rwamarongo Focus of Western Uganda
title_sort elimination of simulium neavei–transmitted onchocerciasis in wambabya–rwamarongo focus of western uganda
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470550/
https://www.ncbi.nlm.nih.gov/pubmed/32588807
http://dx.doi.org/10.4269/ajtmh.20-0195
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